betalactam antibioticspharmacodynamicspenicillin-binding proteinspostantibiotic effectoptical densityinoculum effectendotoxin releaseConsiderable information on the pharmacodynamics of betalactams has accumulated throughout the past 20 years demonstrating a time-dependent killing and some pharmacodynamic differences in ...
Resistance to β-lactam antibiotics in Bacteroides species This was in agreement with the results obtained by others =-=(2, 5, 12)-=-, but a periodic surveillance of the circulation of these enzymes is necessary to detect the emergence of new b-lactamases. To overcome the difficulties ......
B Hernández,ER Reza,M Teresa 摘要: the epidemiology and pharmacology of the b-lactamic antibiotics resistance at hospital level mediate by the presence of ?-lactamasas requires of their precise identification, possible through the gene sequence that can be identified using bioinformatics tools and ...
Mechanisms of action Antibiotics produce their effects through a variety of mechanisms of action. A large number work byinhibitingbacterialcell wallsynthesis; these agents are referred to generally as β-lactam antibiotics. Production of the bacterial cell wall involves the partial assembly of wall comp...
B Schable,DL Rhoden,R Hugh,... - 《Journal of Clinical Microbiology》 被引量: 75发表: 1989年 Classification of plasmids in Pseudomonas aeruginosa beta-Lactamases are the major defense used by bacteria to overcome the effects of penicillins, cephalosporins and related beta-lactam antibiotics. In...
β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity Nat Commun, 4 (2013), 10.1038/ncomms2607 Google Scholar Gutierrez et al., 2017 Arnaud Gutierrez, S. Jain, P. Bhargava, M. Hamblin, M.A. Lobritz, J.J. Collins Understanding and Sensitizi...
As beta-lactam antibiotics are different, they are able to stimulate different levels of beta-lactamase production. The enzymes in group I are found in the Enterobacteriacea family as well as P. aeruginosa. Studies have also shown the shift of enzymes from chromosome to plasmid in some strains...
In comparing DILIrank with DILIst, there were three subgroups where there was a ≥100% increase in the number of drugs in the category (hypnotics and sedatives; beta-lactam antibacterials; and antipsychotics) (Fig. 2b). Three of the high-frequency pharmacological subgroups (direct acting ...
Other compounds with a predictive probability of ≥ 0.80 for increasing the lifespan ofC. elegansincluded alloin, a constituent ofaloe verawith a predictive probability of 0.81, as well as the antibiotics fidaxomicin (predictive probability = 0.84), rifapentine (predictive probability = ...
In addition, 233 EptA/B/C (mcr-like) sequences from one comparative study [31] were also included (no duplication with the cleaned 16,967 sequences). The final mcr-like dataset contained 17,200 sequences (Fig. 1c). Phylogenetic tree implementation To deduce the antibiotics resistance of ...