All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so primarily by inhibiting repolarizing potassium currents. Therefore, these compounds are often referred to as “potassium channel...
Class III, potassium-channel blockers; Class IV, calcium-channel blockers; and miscellaneous antiarrhythmics or unclassified antiarrhythmics. Class II antidysrhythmic drugs inhibit beta-adrenergic activation of adenylate cyclase and reduce sinoatrial node andatrioventricularnode activity. They prolongatrioventr...
Class III drugs (blockers of potassium channels) are mostly characterized by reverse rate-dependence (loss of class III action at faster rates). However, this property cannot be attributed to reverse use-dependence, i.e., binding to channels in the rested state. It is more likely due to ...
The classes include (1) sodium channel blockers, (2) β-adrenoceptor blockers, (3) potassium channel blockers, (4) calcium channel blockers, and (5) selective bradycardic drugs. 6.33.5.2.1.1 Class 1 antiarrhythmic drugs are all sodium channel blockers All Class 1 drugs block cardiac ...
These agents must be differentiated from pure class III potassium channel blockers, such as the dextro isomer form of sotalol, which is linked to increased mortality compared with placebo in post-myocardial infarction patients with reduced ventricular function or a history of heart failure....
The ability of sodium channel blockers to decrease conduction velocity (class I action) is more pronounced with rapid heart rates. Drugs with class III action increase action potential duration and refractoriness in the heart. Most drugs with class III actions, currently being developed, produce ...
potassium channel blockerspsoralensThe effects of the medicinal plant rue (Ruta graveolens L.) on MS-related visual-field defects was tested. In five of nine patients the scotomata were reduced by a single dose of an aqueous extract of 3 g of the drug; the effect was reversible, appearing...
Keywords: dofetilide; DC031050; class III antiarrhythmic agent; hERG; KCNQ; Kv1.2; delayed rectifier potassium current Acta Pharmacologica Sinica (2012) 33: 728–736; doi: 10.1038/aps.2012.41; published online 21 May 2012 Introduction Potassium channel blockers are categorised as class III ...
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Predictive pharmacophore models were developed for a large series of I Kr potassium channel blockers as class III antiarrhythmic agents using HypoGen in Ca... LP Du,KC Tsai,MY Li,... - ...
S Matsumura - 《Japanese Journal of Soil Science & Plant Nutrition》 被引量: 318发表: 1988年 Cloning and functional expression of a rat heart KATP channel. Describes the expressed and cloned potassium channels that are ATP-sensitive isolated from a rat heart. Methodology; Observation of channel ...