β-内酰胺酶(beta-lactamase)是一类酶,主要负责水解β-内酰胺环,这是β-内酰胺类抗生素分子中的一个环结构。这一类抗生素包括青霉素、头孢菌素等。β-内酰胺环的水解导致了这些抗生素的失活,从而增加了细菌对这些药物的耐药性。 β-内酰胺酶的存在是细菌抗药性的一个主要机制。这些酶可以分解与其相互作用的β-内...
Mechanisms of antibiotic resistance: QM/MM modeling of the acylation reaction of a class A beta-lactamase with benzylpenicillin. Understanding the mechanisms by which beta-lactamases destroy beta-lactam antibiotics is potentially vital in developing effective therapies to overcome ba... Johannes,C,Hermann...
Furthermore, 尾-lactamase class D are oxacillinases that are located both on chromosomes (carbapenem-resistant A. baumannii ) and intestinal bacterial plasmids. The class B beta-lactamase possess a double zinc moiety as a characteristic feature, and hence, the term metallo-beta-lactamase (MBL) ...
耐性菌感染症治療の実際 4.ESBLs産生菌 ClassB β-lactamase産生菌感染症 渡辺彰 Progress in Medicine 18, 2672-2676, 1998 渡辺彰 - 《Progress in Medicine》 被引量: 0发表: 1998年 产ESBL大肠埃希菌致血流感染的临床特征及危险因素分析 (extended spectrum β-lactamase,ESBL)情况及药敏结果等.结果:共纳...
INHIBITORS OF CLASS B AND CLASS D β-LACTAMASES The present invention relates to broad spectrum β-lactamase inhibitors; more particularly, inhibitors of Class B metallo (MBL) and Class D (OXA) β-lactamases. A method of treating a bacterial infection is provided, wherein the method c... DM...
www.nature.com/scientificreports OPEN A new class A beta‑lactamase gene blaCAE‑1 coexists with blaAFM‑1 in a novel untypable plasmid in Comamonas aquatica Ying Li 1,2, Chengju Fang 1, Xu Wang 1, Qian Liu 3, Yichuan Qiu 1, Xiaoyi Dai 1...
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases Article Open access 29 July 2020 Efflux pump-mediated resistance to new beta lactam antibiotics in multidrug-resistant gram-negative bacteria Article Open access 29...
The other Streptomyces subgroup shares a common branch point with the rest of the class A beta-lactamases, showing this subgroup as the origin of the non-actinomycete class A beta-lactamases. The non-actinomycete class A beta-lactamase phylogenetic tree suggests a spread of these beta-lactamases ...
Negligible influence of metals on -lactamase activity ruled out that Sml-1 is a Zn2+-dependent class B beta-lactamase. Rather, sequence motifs such as SITK, YSN, and HDG forming the active core in a hypothetical structure may be typical for class C beta-lactamases. Based on the results, ...
beta-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl transfer to specific amino acid acceptors. beta-Lactamases from all three classes, A, B, and C, catalyze the hydrolysis of specific acyclic depsipeptide (PhCH2CONHCR1R2CO2CHR3CO2H) analogs of acyl-D... R,F,Pratt,... - ...