Class III Antiarrhythmics (Potassium Channel Blockers)General Pharmacology All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so primarily by inhibiting repolarizing potassium currents....
6.33.5.2.1.1 Class 1 antiarrhythmic drugs are all sodium channel blockers All Class 1 drugs block cardiac sodium channels. However, on the basis of the frequency-dependent nature of the block, and the presence or absence of concomitant potassium channel blocking actions resulting in action potentia...
potassium channel blockersrecovery of V̇maxelectrophysiologyPurkinje fibres1The frequency-dependent electrophysiological effects of UK-68,798 in concentrations of 1, 3, 10 and 30 nm were examined in isolated cardiac Purkinje fibres of the dog at both a number of constant rates of stimulation and...
potassium channel blockerspsoralensThe effects of the medicinal plant rue (Ruta graveolens L.) on MS-related visual-field defects was tested. In five of nine patients the scotomata were reduced by a single dose of an aqueous extract of 3 g of the drug; the effect was reversible, appearing...
Keywords: dofetilide; DC031050; class III antiarrhythmic agent; hERG; KCNQ; Kv1.2; delayed rectifier potassium current Acta Pharmacologica Sinica (2012) 33: 728–736; doi: 10.1038/aps.2012.41; published online 21 May 2012 Introduction Potassium channel blockers are categorised as class III ...
Describes the cloning and expression of an inward rectifier potassium-channel subunit in a rat's heart. Ashford,LJ M.,Bond,... - 《Nature》 被引量: 415发表: 1995年 Nitrogen Losses due to Volatilization in Application of Cattle Urine to Upland Soil When cattle urine is applied to upland so...
Effect of almokalant, a selective potassium channel blocker, on the termination and inducibility of paroxysmal supraventricular tachycardias: a study in pa... Almokalant is a newly developed selective blocker of the delayed outward K+ current and exhibits the electrophysiological properties of a cla...
The specific BK<sub class="a-plus-plus">Ca</sub> channel blockers charybdotoxin and iberiotoxin and the nonselective K<sup class="a-plus-plus">+</sup> channel blocker tetraethylammonium at concentrations more specific to the BK<sub class="a-plus-plus">Ca</sub> channel were ...
3. Gellens, M. E. et al. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc. Natl Acad. Sci. USA 89, 554–558 (1992). 4. Viswanathan, P. C. & Balser, J. R. Inherited sodium channelopathies: a continuum of ...
The large conductance Ca<sup class="a-plus-plus">2+</sup>-activated K<sup class="a-plus-plus">+</sup> (BK<sub class="a-plus-plus">Ca</sub>) channel in vascular smooth muscle cell (VSMC) is an important potassium channel that can regulate vascular tone. Recent work has demonstrate...