56. In brief, mAbs were measured as a function of reduction in luciferase (Luc) reporter gene expression after a single round of infection in TZM-bl cells (obtained through the NIH AIDS Reagent Program, Division
patients11. A similar result was reported in a phase I trial of NY-ESO-1 TCR-T cell therapy in advanced soft tissue sarcoma13. Although tumor-reactive CD4 T cells have been identified for decades14, almost all of the TCR-T therapy developed in clinical stage are HLA-I restricted CD8 TC...
Date of Patent: June 11, 2013 Assignee: Biotix, Inc. Inventor: Arta Motadel Reagent delivery system Patent number: 8298497 Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the ap...
Recently, interest has grown in the physiologic properties of the π class of GST (GSTP), not only because of its function in drug detoxification but also because of its possible roles in cell transformation and carcinogenesis (11,12). GSTP activity has been used to evaluate the potency of ...
HCl will be the limiting reagent in the reaction and Zn will be excess reagent. 4. Write chemical equations for the following equations and balance them. a) Carbon + Oxygen → Carbon-di-oxide b) Nitrogen + Oxygen → Nitrogen monoxide ...
The supernatant was warmed to 37°C for few minutes until it turned cloudy following which it was centrifuged at 11,000 rpm at room temperature for 10 min (Beckman JA-20 rotor) to separate the soluble and detergent-enriched phases. The soluble phase was removed, and Triton X-114 was ...
an intra-domain that is relatively similar to the apo state (RMSD7TM4.0 Å, which is the sum of the Cα RMSDs of the 7TMs from the apo conformation)12. Consequently, such reorientation engenders a TM6–TM6 interface, appearing to be a hallmark of class C GPCR activation11,47...
The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes. Several G-quadruplexes can be formed in the HIV-1 long terminal repeat promoter region and their stabil
In certain embodiments, the polypeptide of the present invention comprises or consists essentially of any one of SEQ ID NOs: 11-43 or 46-48. In certain embodiments, a cell-targeted molecule of the present invention comprises a cell-targeting moiety or agent, and any polypeptide of the present...
To overcome this limitation in sensitivity when recombinant MHC class II molecules are used as detection reagent, polymerization of the molecules into tetramers or pentamers have been necessary11. The production of such polymers involves a multi-step protocol with substantial handling. The use of ...