9a,b). By contrast to membrane-anchored mucins, these lines did not show any protective effect against SARS-CoV-2 infection. Consistent with its depletion in our GOF screen, MUC5AC but not MUC5B upregulation increased susceptibility to the SARS-CoV-2 WA/1 clinical isolate and all tested ...
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REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Mouse monoclonal anti-CD3 (UCHT1) Beckman Coulter Cat #: A07748; RRID:AB_1575956 Mouse monoclonal anti-CD1b (SN13) Biolegend Cat #: 329108; RRID:AB_10613102 Mouse monoclonal anti-CD4 (13B8.2) Beckman Coulter Cat #: A94685 Chemicals, Peptides, ...
18 If more than one T cell clone grows from the same well after limiting dilution, it may lead to incorrect pairing. (4) Up to one-third of mature T cells may express two functional TCRα chains, and likely only one of the TCRα chains contributes the anticipated specificity.19 The ...
drug resistance and dose-limiting toxicities are the major problems leading to termination or failure of successful treatment in the clinic3. In particular, chemotherapy can reduced or damaged immune function and negated the therapeutic benefits4. Thus, novel anti-cancer drugs are required to kill ...
In addition to standard RNA-seq quality control procedures (see “Methods” section), we also assessed RNA-seq quality by principal components analysis (PCA) and did not observe any major effect of sex, batch, and age in the first two principal components, which explained over 50% of the ...
Our study further demonstrates that PKP2, a common PB1 interactor, inhibits the IAV polymerase activity, thereby limiting viral infection. Results Mapping IAV–host protein interactomes. To uncover the comprehensive IAV–host protein interactions, we first performed affinity purification coupled with ...
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, includin
increased production of HLA-I molecules (Supplementary Fig.4m). However, no obvious change was observed for the noncHLAIp repertoire, with 60% of the identified noncHLAIp remaining unaltered by IFNγ treatment, suggesting that transcription is the limiting step in the presentation of noncHLAIp, ...
Several proteins unique only to the head louse and/or nits have been identified using data from the Louse Genome project. An immunochemical reagent-coated lateral flow test strip is used to determine if a subject has lice. The user uses a comb to brush a subject's hair, inserts the comb ...