当前, 新型H5N1、H5N6和H5N8禽流感病毒在全球范围广泛传播,并导致了大量鸟类感染和死亡。自 2020 年以来,禽流感病毒在人与动物之间的互动频繁发生。为了深入了解新型 H5 亚型禽流感病毒(即 H5N1、H5N6 和 H5N8),我们利用2021年1月至20...
自1980年WHO宣布天花病毒被人类彻底灭绝之后,猴痘病毒已成为全球公共卫生领域威胁最大的正痘病毒。 猴痘病毒(Mpox virus,MPXV),是一种有包膜的双链DNA病毒,属于痘病毒科、正痘病毒属的成员,1958年首次分离自发热的猕猴体内,1970年在刚果首次报道感染人感染病例。2021年之前,猴痘病毒主要流行区域一直局限于中非和西非...
This is a report of HPAI A(H5N1) virus clade 2.3.2.1a infection in a child traveler returning to Australia from India in February 2024. The 2.5-year-old child, a previously healthy girl, became ill in Kolkata, India. Upon returning to Australia, she deteriorated and required intensive care...
In March 2024, clade 2.3.4.4b A(H5N1) virus was first detected in dairy cattle in the USA, with subsequent detection in numerous states2, leading to more than a dozen confirmed human cases3,4. In this study, we used the ferret, a well-characterized animal model that permits concurrent ...
RepHA-Vietnam vaccinated mice had low but detectable virus neutralization (VN) titers of 1:20 against homologous A/Vietnam but no detectable neutralization against heterologous A/bovine (Fig. 2c). RepHA-Bovine vaccinated mice had VN titers of 1:30 against homologous A/bovine but no detectable...
The spread of H5N1 virus into a wide range of avian and mammalian species may facilitate the adaptation of the virus to human populations. In the present s... Q Liu,J Ma,K Zheng,... - 《Virus Research》 被引量: 70发表: 2010年 Emergence of novel clade 2.3.4 influenza A (H5N1) vir...
To effectively tackle the virus, an HIV-1 vaccine should elicit both potent and broad immunity against the Env protein. A multitude of approaches have been used to develop HIV-1 vaccine candidates that can trigger antibody and/or T cell immunity. These include the use of Env as an immunogen...
Mpox is a disease resulting from infection with the mpox virus. It was previously known as monkeypox, but the World Health Organization(WHO) changed its nameafter an outbreak in 2022 that spread to Europe, Canada and the United States. Characterized by a distinctive rash, this viral infection...
下述实施例中clade2.1.3分支H5N1禽流感病毒记载在如下文献中:Zhang,Y.,Sun,Y.,Sun,H.,Pu,J.,Bi,Y.,Shi,Y.,Lu,X.,Li,J.,Zhu,Q.,Gao,G.F.2012.A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1influenza virus in mice.J.Virol....
Due to the shared and distinct evolutionary history of these phages, we propose to create a new phage genus “Kp15virus” within the Tevenvirinae subfamily. In silico genome analysis reveals two unique putative homing endonucleases of KP27 phage, probably involved in unrevealed mechanism of DNA...