cl caspase-1什么意思 Caspase 是一类与凋亡密切相关的蛋白水解酶家族,以Caspase前体酶原的形式存在大多后生动物的细胞中 半胱天冬酶1,反正我没看懂。
该制剂利用特异性靶向肝脏的载体Pre-S1肽将caspase-1抑制剂特异性靶向肝细胞,既有利于通过终止肝细胞内的caspase-1活化来阻断由损伤肝细胞释放的内源性危险信号导致的肝内持续性慢性炎症,进而阻断肝细胞的继发性损伤,也有利于减少caspase-1广泛抑制可能导致的机体不良反应,从而对肝细胞起到特异有效的保护,可用于制备...
CL750-81482 targets Caspase 1 in WB applications and shows reactivity with human samples. Tested Reactivity human Host / Isotype Rabbit / IgG Class Recombinant Type Antibody Immunogen Caspase 1 fusion protein Ag11143 Full Name caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta,...
The collection number of the caspase-1-ES cell line is CCTCC No.C201193. The invention also provides a preparation method and application of the cell line. The invention has the advantages that: caspase-1 is transferred into an embryonic stem (ES) cell for the first time, and the ...
Zehendner CM, Librizzi L, de Curtis M, Kuhlmann CR, Luhmann HJ (2011) Caspase-3 contributes to ZO-1 and Cl-5 tight junction disruption in rapid anoxic neurovascular unit damage. PLOS ONE 6(2): e16760. doi:10.1371/journal.pone.0016760. PubMed: 21364989....
首次在ES细胞内高表达caspase-1,证实caspase-1激活后通过引发DNA损伤导致体外未分化的caspase-1-ES细胞死亡,降低ES细胞移植成瘤的风险;首次发现在分化的ES细胞内高表达caspase-1对细胞无显著影响,有助于维持ES细胞治疗的疗效;既提高了胚胎干细胞移植的安全性又保留治疗帕金森病和其他神经疾病的效果,可以在干细胞移植...
and an agent for preventing and/or treating an inflammatory disease, all of which comprise inhibiting the binding of NOD2 to procaspase-1; a method of identifying a compound that inhibits the binding of NOD2 to procaspase-1; and a reagent kit for use in the identifying method are provided...
Caspase抑制剂及其应用本发明涉及新的由通式(I)表示的二肽:其中RCNdoi:CN1176941 C蔡遂雄E·维比尔王炎G·B·密勒斯D·R·格林
1,2-苯并异噻唑-3-酮类化合物在抑制Caspase-3活性中的应用。本发明提供1,2-苯并异噻唑-3-酮类化合物在制备用于治疗由Caspase-3介导的疾病的药物中的应用,属于药物化学领域,所述化合物具有如下所示的结构式(I)。饶子和杨诚刘大志吴婷婷刘伟傅晟李爽
The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.doi:EP2412707 A2Guy BrenchleyJean-Damien Charrier