The collection number of the caspase-1-ES cell line is CCTCC No.C201193. The invention also provides a preparation method and application of the cell line. The invention has the advantages that: caspase-1 is transferred into an embryonic stem (ES) cell for the first time, and the ...
Mouse hepatitis virus (MHV) infection in murine 17Cl-1 cells results in apoptotic cell death. Inhibition of MHV-induced apoptosis by the pancaspase inhibitor Z-VAD-FMK promoted virus production late in infection, indicating that apoptosis could be a host response to limit the production of viral...
Mouse hepatitis virus (MHV) infection in murine 17Cl-1 cells results in apoptotic cell death. Inhibition of MHV-induced apoptosis by the pancaspase inhibitor Z-VAD-FMK promoted virus production late in infection, indicating that apoptosis could be a host response to limit the production of viral...
首次在ES细胞内高表达caspase-1,证实caspase-1激活后通过引发DNA损伤导致体外未分化的caspase-1-ES细胞死亡,降低ES细胞移植成瘤的风险;首次发现在分化的ES细胞内高表达caspase-1对细胞无显著影响,有助于维持ES细胞治疗的疗效;既提高了胚胎干细胞移植的安全性又保留治疗帕金森病和其他神经疾病的效果,可以在干细胞移植...
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage. PLoS One. 2011; 6 (2):e16760.Zehendner CM, Librizzi L, de Curtis M, Kuhlmann CR, Luhmann HJ. Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic ...
Moreover, Grb7 can affect Caspase3 cleavage of Hax1 isoform 1 in vitro , and Grb7 expression may slow Caspase3 cleavage of Hax1 isoform 1 in apoptotic HeLa cells. Finally, Grb7 is shown to increase cell viability in apoptotic HeLa cells in a time-dependent manner. Taken together, these...
该制剂利用特异性靶向肝脏的载体Pre-S1肽将caspase-1抑制剂特异性靶向肝细胞,既有利于通过终止肝细胞内的caspase-1活化来阻断由损伤肝细胞释放的内源性危险信号导致的肝内持续性慢性炎症,进而阻断肝细胞的继发性损伤,也有利于减少caspase-1广泛抑制可能导致的机体不良反应,从而对肝细胞起到特异有效的保护,可用于制备...
and an agent for preventing and/or treating an inflammatory disease, all of which comprise inhibiting the binding of NOD2 to procaspase-1; a method of identifying a compound that inhibits the binding of NOD2 to procaspase-1; and a reagent kit for use in the identifying method are provided...
1,2-苯并异噻唑-3-酮类化合物在抑制Caspase-3活性中的应用。本发明提供1,2-苯并异噻唑-3-酮类化合物在制备用于治疗由Caspase-3介导的疾病的药物中的应用,属于药物化学领域,所述化合物具有如下所示的结构式(I)。饶子和杨诚刘大志吴婷婷刘伟傅晟李爽
The invention relates to an application of a 1,2-benzisothiazole-3-ketone compound in inhibiting caspase-3 activity, provides the application of the 1,2-benzisothiazole-3-ketone compound in preparing a medicine for treating diseases induced by caspase-3, and belongs to the field of medicinal ...