结果表明:鞣花酸对小肠上皮细胞具有保护作用,与空白对照组相比,不同浓度鞣花酸作用细胞12h后,细胞凋亡率,Bax,cle-Caspase-3的含量下降(P<0.05,或P<0.01),细胞增值率,Bcl-2/Bax的含量升高(P<0.05,或P<0.01).研究结果说明,抑制细胞的抗凋亡机制可能与抑制Bax,cle-Caspase-3的表达以及提高Bcl-2/Bax的比率有...
caspase-2 is localized to the Golgi complex, where it cleaves golgin-160 at a unique site not susceptible to cleavage by other caspases with very similar tetrapeptide specificities. Early cleavage at this site precedes cleavage at distal sites by other caspases. Prevention of cleavage at the uniqu...