Thus, the focus has shifted to very early stages of chronic kidney disease, which we hope to identify with new biomarkers. Those biomarkers could be of importance in defining a new disease, or at least a new stage of disease. It is common practice in other areas of medicine, where pre-...
We propose a complementary paradigm based on complexity science to deepen our understanding of the disease. Complexity science views a population as system that has several dynamically interacting and inter-dependent sub-systems and is 'open' to the 'outer' environment Health outcomes or epidemics ...
which regulates electrolyte and water homoeostasis and plays a crucial role in the pathogenesis of cardiovascular and kidney disease, emerged as a pivotal target4. Steroid-based mineralocorticoid receptor antagonists (MRAs) could successfully treat cardiovascular disease, but had ...
One of the key aspects of the 2012 KDIGO guidelines concerning CKD diagnosis is the classification of the disease based on the level of kidney function and the presence of kidney damage. This classification system helps healthcare providers determine the severity of the disease and tailor treatment ...
The prevalence of chronic kidney disease (CKD) is increasing worldwide and is considered an independent risk factor for the development of coronary artery disease (CAD). Overall, patients with CKD are at significantly higher risk of developing of CAD than those in the general population without ...
How is chronic kidney disease (ckd) diagnosed? Abnormal kidney function test results may signal the first step of your CKD journey. After a simple blood test, your doctor will help determine your unique needs by: 1. Calculating your glomerular filtration rate (GFR) Your GFR is a measurement ...
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the western world. The excess mortality in NAFLD patients is strongly related to extrahepatic comorbidities. Recently, an association between NAFLD and chronic kidney disease (CKD) has been reported in various...
Cardiovascular disease is the main cause of early death in the settings of chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), and ageing. Cardiovascular events can be caused by an imbalance between promoters and inhibitors of mineralization, which leads to vascular calcification. This ...
Antagonist, blocker A, B or I? Or inhibitor Which is “correct”? Ang II(AT1) AIIA, or ARB 1st of a New Class – AIIAs Specific Mechanism of Action (AT1) Excellent Tolerability Blood Pressure Lowering Comparable to Other Antihypertensive Drugs Stay on Therapy End Organ Protection Altering ...
It is a non-occlusive condition. Medial vascular calcification leads to increased stiffness of the arterial wall and disturbances in blood flow, which can be assessed by aortic pulse wave velocity measurements.2,3 Medial calcification is observed in young and middle-aged CKD patients without ...