CKD patients: the dilemma of serum PTH levels. Pontoriero Giuseppe,Cozzolino Mario,Locatelli Francesco,Brancaccio Diego. Nephron. Clinical practice . 2010G Pontoriero,M Cozzolino,F Locatelli.CKD patients: the dilemma of serum PTH levels. Nephron Clin Pract . 2010...
继发性甲状旁腺功能亢进是慢性肾脏病患者常见的并发症,它不仅影响骨代谢,还可能增加患者的骨折风险。然而,关于甲状旁腺激素(PTH)水平与骨折风险之间的关系是否线性或呈 U 形,目前证据尚不一致。 7月 18 日,《Kidney International Reports》杂志在线发表了一项新的研究,旨在探讨血液透析患者中 PTH 水平与骨折风险之间...
此外,PTH 水平的变化也与骨折风险相关,随着 PTH 水平的降低,骨折风险也随之降低。 研究表明,较低的 PTH 水平与骨折风险的逐步降低有关。这一发现提示我们,对于血液透析患者,维持适宜的 PTH 水平可能对预防骨折具有重要意义。此外,研究还指出,年龄较大、女性以...
[2]Tentori F, Blayney MJ,Albert JM, et al. Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study(DOPPS). Am J Kidney Dis,2008,52(3):519-530 [3]Kalantar-Zadeh K, Kuwae N, Regidor DL, et a...
Intact parathyroid hormone (PTH) levels In certain cases, the following tests may also be ordered as part of the evaluation of patients with CKD: Serum and urine protein electrophoresis and free light chains: Screen for a monoclonal protein possibly representing multiple myeloma Antinuclear antibodies...
NEFRONA 与 PECERA 两个研究,均通过队列观察发现,骨矿物质参数如钙、磷、PTH,与 CKD 进展和心血管事件发生率密切相关;对于尚未进入透析的 CKD 4 - 5 期患者,积极地控制血清钙、磷、PTH,具有潜在的生存获益。 COSMOS 研究表明血磷在 1.42 mmol/L 时透析患者死亡风险最低,而此次的 PECERA 研究结论表示未进入透...
9、f plasma PTH and phosphate levels and SVLPD is associated with reduction of plasma PTH and phosphate levels and renal osteodystrophy and osteomalacia improve (Aparicio, 1993, 1999, 2001)renal osteodystrophy and osteomalacia improve (Aparicio, 1993, 1999, 2001)The better control of anemia could ...
人体通过甲状旁腺激素(PTH)和成纤维细胞生长因子 23(FGF-23)来维持正常的血清磷水平。 当肾小球滤过率降低时,PTH 和 FGF-23 均可增加尿磷的排泄。FGF-23 还通过降低 1,25-二羟基维生素 D 含量来限制胃肠道对磷的吸收,除了对骨骼的影响外,还与心血管疾病和死亡的风险有关。
* Calcitriol Decreases PTH mRNA Levels Calcitriol binds to VDR and then regulates PTH synthesis via the negative VDRE located upstream from the transcription initiation site of the pre-pro-PTH gene. In this study, rats were treated with calcitriol (100 pmol intraperitoneally).1 Twenty-four hours...
综上骨代谢指标PTH可能对骨代谢指标(N-MID OC、β-CTX、tPINP)具有调节作用,而PTH与N-MID OC、β-CTX、tPINP联合可能对诊断肾性骨病具有一定意义。 文献来源:Xie D, Zhao L, Wu L, Ji Q. The levels of bone turnover markers ...