Moreover, because the alleles of different SNPs within a DNA sequence of limited length tend to be in strong linkage disequilibrium (LD), we hypothesize the variants of miRNA target sites caused by SNPs potentially function as bridges linking the documented cis-SNP markers to the expression of ...
牛CIS基因启动子区SNP及生物信息学研究
Our work identified a novel long-distance cis-regulatory SNP for SCGB1A1, which might contribute to multiple pulmonary diseases.AM J PHYSIOL-LUNG CXiu-Xiong LiTao PengJing GaoJia-Gang FengDan-Dan WuTing YangLi ZhongWei-Ping FuChang Sun...
The cis-SNP effects on gene expression To test the function of the interrogated SNPs of the two adiponectin QTLs, we evaluated the effect of each vari- ant on the levels of transcripts produced from the genes located within these two regions. We surveyed tran- scripts that were robustly ...
A comprehensive analysis of adiponectin QTLs using SNP associa- tion, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation. BMC Med Genomics 2013;6:14....
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Investigating cis-SNP/mRNA level associations of candidate Alzheimer genes in different brain regions of patients and controlsBackground: It has been shown that mRNA levels of many human transcripts are under genetic control. We postulate that some Alzheimer's disease (AD) susceptibility variants ...