The first application of LMM is the cis-SNPs set association test. That is, our objective is to detect whether thepcis-SNPs located within a given gene are simultaneously related to the expression leveleof that gene. Here we only focus on cis-SNPs due to the fact that in terms of previo...
The prediction of gene expression can shed some light on the functional interpretation for identified SNPs in GWASs.doi:10.1186/s12864-017-3759-6Ping ZengXiang ZhouShuiping HuangBioMed CentralBmc GenomicsP. Zeng, X. Zhou, and S. Huang, "Prediction of gene ex- pression with cis-SNPs using ...
选取务川黑牛为试验对象构建DNA池筛查SOCS2,SOCS3和CIS基因SNPs,结果首次在牛中发现CIS基因SNPs位点.在SOCS2基因中快速筛查到的3个SNPs均位于第4外显子内,其中G3456A(Glu→Lys)和G3810A(Val→Ile)为错义突变,T3599C为同义突变;在CIS基因中发现5个SNPs,其中A4086G(Val→Met)为错义突变,位于第3外显子处,其...
下列哪些不是TWAS设计的步骤 A、在eQTL数据中算出对应于该基因的所有的cis-SNPs的一个权重 B、把权重代入到GWAS的数据当中,得到预测基因表达值 C、将预测的基因表达值和复杂疾病或性状建立关联分析 D、利用GWAS中基因表达数据,得到预测的基因表达值
A.在eQTL数据中算出对应于该基因的所有的cis-SNPs的一个权重B.利用GWAS中基因表达数据,得到预测的基因表达值C.把权重代入到GWAS的数据当中,得到预测基因表达值D.将预测的基因表达值和复杂疾病或性状建立关联分析E.将GWAS的基因表达值与复杂疾病或性状建立关联分析相关...
TWAS设计主要分为下面哪三步 A、在eQTL数据中算出对应于该基因的所有的cis-SNPs的一个权重 B、利用GWAS中基因表达数据,得到预测的基因表达值 C、把权重代入到GWAS的数据当中,得到预测基因表达值 D、将预测的基因表达值和复杂疾病或性状建立关联分析
We focused on a small cis-regulatory sequence downstream of ERAP2 as a proof of principle. Here, we showed that disease risk SNPs alter physical interactions with the promoter in immortalized lymphoblast cell lines from autoimmune patients and that substitution of the allele of one common SNP (...
-mer analysis clarifies the cell type dependency of binding specificities and cis-regulatory snps in humans saeko tahara 1 , 2 na1 , takaho tsuchiya 1 , 3 na1 , hirotaka matsumoto 4 , 5 & … haruka ozaki 1 , 3 , 5 show authors bmc genomics volume 24 , article ...
CISJAK-STAT选取务川黑牛为试验对象构建DNA池筛查SOCS2,SOCS3和CIS基因SNPs,结果首次在牛中发现CIS基因SNPs位点.在SOCS2基因中快速筛查到的3个SNPs均位于第4外显子内,其中G3456A(Glu→Lys)和G3810A(Val→Ile)为错义突变,T3599C为同义突变;在CIS基因中发现5个SNPs,其中A4086G(Val→Met)为错义突变,位于第3...
(2006) Cis- regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations. BMC Genomics 7: 235.GuhaThakurta D, Xie T, Anand M, Edwards SW, Li G, Wang SS, Schadt EE. 2006. Cis-regulatory variations: a study of SNPs around genes showing cis-...