Regulatory variants have proven difficult to uncover, so that the causative polymorphisms have largely remained hidden. I will discuss new methods suitable for systematic study of regulatory variants, the nature
We performed comprehensive studies to elucidate the role of both cis-acting variants in 11p15.5 as well as of maternal effect variants in the etiology of ICR1 LOM. Whereas copy number analysis and next generation sequencing in the ICR1 did not provide any evidence for a variant, search for ...
Circular RNA vaccines against SARS-CoV-2 and emerging variants. Cell 185, 1728–1744.e1716 (2022). Article CAS PubMed PubMed Central Google Scholar Kao, C., Zheng, M. & Rudisser, S. A simple and efficient method to reduce nontemplated nucleotide addition at the 3 terminus of RNAs ...
In addition, a number of splicing variants generate more diversity in AP-2 isoforms (55, 56). Our results demonstrated that the binding of nuclear protein to a putative AP-2 binding site was significantly but partially inhibited by cold excess consensus AP-2 oligonucleotides (Fig. 7). To ...
In view of the major advances in the structural analysis of RNA structural elements of SARS-CoV-2 and a few other coronaviruses over the past few years and the progress made in the production of genetically modified coronavirus variants by newly developed reverse-genetic systems, it seems reasona...
(2016). A spectral approach integrating functional genomic annotations for coding and noncod- ing variants. Nat. Genet. 48, 214-220.Hughes JR, et al. High-resolution analysis of cis-acting regulatory networks at the alpha-globin locus. Philos Trans R Soc Lond B Biol Sci. 2...
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It was previously shown that in pea (Pisum sativum), rDNA repeats contain a polar replication fork barrier that blocks progression of the replication machi
International Journal of Molecular Sciences Article A cis-Acting Mutation in the PxABCG1 Promoter Is Associated with Cry1Ac Resistance in Plutella xylostella (L.) Jianying Qin 1,2,†, Fan Ye 2,†, Linzheng Xu 2,†, Xuguo Zhou 3 , Neil Crickmore 4 , Xiao...
The effects of mRNA structure on the activities of the constructs. The activity of β-galactosidase fused with original sequences E1, E5 and C7 was compared to the activities of variants containing synonymous substitutions (marked with asterisks). The nucleotide sequences of the constructs are shown...