Cis -acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos. Nature. 1988; 336 :595–598.Macdonald PM, Struhl G (1988) cis-acting sequences responsible for anterior localiza
Although the entirety of cis-acting sequences affecting the HIF transcriptional cascade cannot be defined with precision, at any given locus it clearly extends beyond the HIF-binding site itself. We therefore sought to test whether the excess overlap with RCC-susceptibility polymorphisms might extend ...
Here, in vitro translation is deployed to compare the role of cis-acting regulatory sequences in P. falciparum and humans. Using parasite mRNAs with high or low translational efficiency, the presence, position, and termination status of upstream “AUG”s, in addition to the base composition of...
floxed) version of tcfap2a which has subsequently been intercrossed with mice expressing Cre recombinase under the control of Wnt1 cis-regulatory sequences... S Brewer,W Feng,H Jian,... - 《Developmental Biology》 被引量: 211发表: 2004年 The regulatory mechanisms that underlie inappropriate tr...
81,136,137 ARE sequences are recognized by RBPs, which generally drive the transcript to degradation by stimulating poly(A) shortening followed by exonucleolytic degradation from either 5′–3′ and/or 3′–5′. Examples of ARE binding proteins are discussed in the next section. Other ...
Many cis-acting sequences consist of AU-rich elements (AREs), most often located in the 3′-untranslated region (3′-UTR) of labile mRNAs. However, cis-acting elements are also found within the coding regions and 5′-UTRs of various mRNAs (e.g. c-fos, c-myc) (19). AREs often ...
Several cis-acting regulatory sequences functioning at the level of mRNA or nascent peptide and specifically influencing transcription or translation have been described. These regulatory elements often respond to specific chemicals. We have developed a
1A–C). In addition, internal conserved structures were identified in their 3Dpol domains, in the 2CATPase coding sequence of poliovirus (PV) and VP1 or 2A sequences of HRVs. 1.1.1.1. 5′ NTR (oriL) The 5′ noncoding region or oriL (origin of replication at the left) of ...
7). Therefore, as for the enzyme–substrate relationship, the corresponding SUB RNA sequences would be ideally better if they ended as designed. A circRNA with two IRES hampers the protein expression of each other To have a circRNA with multiple functions, we wondered whether circRNA could ...
4B). These results suggest that the nucleotide sequences in the stem, especially 3′ side of the SLD-LargeS, but not its stem structure, are important for the accumulation of negative-strand RNA1. For SLE, all forms with mutations in this region failed to accumulate negative-strand RNA (...