Circulating tumor cellsDrug sensitivity assaysPersonalized medicineCirculating tumor cells (CTCs) play a crucial role in metastasis and became an emerging topic in today's cancer research. In addition, the analysis of CTCs in liquid biopsies will be a valuable tool for prognosis prediction and real ...
1. Circulating tumor cells as metastatic seeds Distant metastasis represents the leading cause of cancer-associated mortality in solid tumor as an incurable stage of the cancer disease. During metastasis, cells detach from the primary tumor (or already established distant sites), intravasate into the...
mesenchymal transition (EMT) of tumor cells9, the role of exosomes in supporting metastasis10, circulating tumor cells (CTCs) and CTC clusters in seeding metastatic colonies11, and complex interactions between tumor cells and microenvironment12, have gradually been unmasked, along with the discovery o...
mesenchymal transition (EMT) of tumor cells9, the role of exosomes in supporting metastasis10, circulating tumor cells (CTCs) and CTC clusters in seeding metastatic colonies11, and complex interactions between tumor cells and microenvironment12, have gradually been unmasked, along with the discovery o...
The CellSearch®System is the first diagnostic test used to automate the capture and detection of CTCs, tumor cells that have detached from solid tumors and entered the patient’s blood. The CellSearch®System assesses CTCs to determine the prognosis and overall survival of ...
Mohamed Suhaimi, Nur-AfidahTan, Min-HanExpert Review of Precision Medicine and Drug DevelopmentMohamed Suhaimi NA, Tan MH. Circulating tumor cells and circulating tumor DNA in colorectal cancer. Expert Rev Precis Med Drug Dev 2016;1:181-94....
Rudiger N, Stein E, Schill E, Spitz G, Rabenstein C, Stauch M, et al. Chemosensitivity testing of circulating epithelial tumor cells (CETC) in vitro: correlation to in vivo sensitivity and clinical outcome. J Cancer Ther. 2013;4:597–605....
Analyses of circulating tumor cells have been shown to be effective for the detection of cancer relapse and prognosis prediction. However, research regarding its utility in sarcoma remains scarce. In this study, the microfluidic chip-type cell sorter On-chip Sort was used to construct a system fo...
Circulating tumor cells ( CTCs ) have long been assumed to be the substrate of cancer metastasis. However, only in recent years have we begun to leverage the potential of CTCs found in minimally invasive peripheral blood specimens to improve care for cancer patients. Currently, CTC enumeration is...
In 1869, Thomas Ashworth, an Australian physician, first identified cells similar to cancer cells in blood drawn from the saphenous vein [1]. In 1889, Stephen Paget proposed a ‘seed and soil’ hypothesis, in which certain tumor cells (“seeds”) have a specific affinity for the environment...