The article presents the summary of a study on circulating tumour cells (CTCs). It states that the detection and analysis of CTCs are vital in the individuation of cancer diagnoses and treatment. It says that CTCs can accumulate mutations, genetic adaptation, and have the ability to self-renew...
Circulating tumor cells: biology and clinical significance Article Open access 22 November 2021 Biology, vulnerabilities and clinical applications of circulating tumour cells Article 09 December 2022 Liquid biopsy enters the clinic — implementation issues and future challenges Article 20 January 2021...
However, there are several obstacles that CTCs must overcome in order to successfully detach from the primary tumor tissue, including: 1) Adhesion: Extracellular matrix (ECM) and surrounding cells in the tissue of the primary tumor are both firmly adhered to by cancer cells, which are typically ...
The high mortality rate in patients with lung cancer is largely due to the high recurrence and metastasis rate.Circulating tumor cells,a special kind of peripheral blood cells,exist in peripheral blood of patients,and it can be used as a biomarker for monitoring tumor.Recently,we have seen dram...
Harris LN, Solomon N, Roberts L, Ngo T, Abi Raad R, Gioioso C, Kuter I, Smith B, Iglehart JD, Friedman P et al (2005) Detection and monitoring of circulating tumor cells (CTCs) by CK-19 mRNA in breast cancer patients treated with neoadjuvant chemotherapy: a marker of early recurrence...
The major cause of cancer-associated mortality is tumor metastasis, a disease that is far from understood. Many studies have observed circulating tumor cells (CTCs) in patients' circulation systems, and a few latest investigations showed that CTC clusters have a potentially high capacity of metastasi...
1. Circulating tumor cells as metastatic seeds Distant metastasis represents the leading cause of cancer-associated mortality in solid tumor as an incurable stage of the cancer disease. During metastasis, cells detach from the primary tumor (or already established distant sites), intravasate into the...
Recent progress in the analysis of blood samples for circulating tumor cells (CTC) or cell-free circulating tumor DNA (ctDNA) provides rapid, cost-effective, and noninvasive “liquid biopsy” surrogates, which give important complementary information on therapeutic targets and drug resistance mechanisms...
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against ca
Circulating tumour cells in cancer patients: challenges and perspectives. Trends Mol. Med. 16, 398–406 (2010). PubMed Google Scholar Mostert, B. et al. Gene expression profiles in circulating tumor cells to predict prognosis in metastatic breast cancer patients. Ann. Oncol. 26, 510–516 ...