Circular RNAs (circRNAs), a type of non-coding RNA, are single-stranded circularized molecules characterized by high abundance, evolutionary conservation and cell development- and tissue-specific expression. A large body of studies has found that circRNAs exert a wide variety of functions in diverse...
Cardiotoxicity is a serious challenge cancer patients face today. Various factors are involved in cardiotoxicity. Circular RNAs (circRNAs) are one of the effective factors in the occurrence and prevention of cardiotoxicity. circRNAs can lead to increased proliferation, apoptosis, and regeneration of cardi...
- 《Environmental Toxicology》 被引量: 0发表: 2024年 CircROBO1 promotes retinal Y79 cell tumor invasion by targeting KLF5 the structural stability of circular circROBO1 in retinal Y79 cells;cytoplasmic and nuclear RNAs of retinal Y79 cells were extracted for localization ... YF Liu,ZW Zhang,...
摘要: A total of 34 circRNAs were differently expressed in rainbow trout skin after IHNV infection.The DE circRNA source gene was related to immune-related pathways such as TLR and NLR pathway.Identified two pairs of ceRNA that may have a vital role in rainbow trout antiviral immunity.关键词:...
Osteoarthritis (OA) is the most common age-related joint disease characterized by chronic inflammation, progressive articular cartilage destruction, and subchondral sclerosis. Accumulating evidence suggests that circular RNAs (circRNAs) play key roles in OA, but the function of circSLTM in OA remains...
In addition to their canonical structure and ability to bind proteins, circular RNAs may form complex three dimensional structures and conformations [1]. This allows circular RNAs to acquire additional impact on gene expression and protein binding, which is distinct from the mechanisms their analogous...
Alterations of RNA editing that affect the secondary structure of RNAs can cause human diseases. We therefore studied RNA editing in failing human hearts.
Accumulating evidence has revealed that aberrant Circular RNAs (circRNAs) expression plays important roles in carcinogenesis and tumor progression. However, their role in non-small cell lung cancer (NSCLC) remains unclear. In this study, we first used ci
[111]). The frequency and occurrence of these less common mycotoxins should ideally be subject to risk assessment. Finally, many mycotoxins co-occur in the same crop, yet, worldwide regulations only consider the toxicology of a single mycotoxin [112]. Little is known whether combinations of ...
Circular RNAs(circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including...