Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome sequ
Circular RNA (circRNA) is a candidate for next-generation messenger RNA therapeutics owing to its remarkable stability. Here we describe trans-splicing-based methods for the synthesis of circRNAs over 8,000 nucleotides. The methods are independent of bac
Class to return a list or single item Classes not recognized in their unit test code clean up code that simply removes the last comma of a comma separated string ? Clear Date time Picker Value Clear Selected Value in ComboBox Clearing Excel Sheet Clearing large arrays from memory Click html ...
Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and tumorigenicity. Nevertheless, HGF/MET-targeted therapy has shown limited clinical benefits in GBM patients, suggesting hid...
The criterion of prohibiting the purchase of single-use disposable plastic products was identified which can be referred to the most desirable-based option of refusing products made of unsustainable material. Additionally, the criteria encouraging the procurement of reused, reusable and repaired products ...
The same staff count maximum value (9663) has been observed for “recycle”, “reduce”, and “renew”, corresponding to a single company with all those RE strategies included in its profile. From another point of view, the cumulative number of followers for each RE strategy can probably ...
That gives you a full installation stack for Python projects. Which is all you need for anything else you do. Yes, it's complex, but that's a consequence of the (deliberate) decision not to mandate a single build backend, but allow projects to choose among many.Sorry...
(114 of 157) circRNAs could be regulated by GWAS-linked circQTL SNPs located in flanking introns and circRNA regions, which also suggested the important roles of flanking introns and circRNA regions in pathogenesis. The colocalization between circQTL and GWAS loci provides novel insights into the ...
There is no single best option for CE strategies. Many circularity strategies are complimentary and also fit to varying industrial and societal contexts (Moreau et al., 2017) To avoid ambiguity, the current work defines CE and CE strategies as follows. Circular Economy is a production and ...
Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well understood. We investigate circRNA expression in the pediatric malignanc