Our biological rhythms are entrained or reset by these zeitgebers each day. If we are removed from the influence of these external time cues (e.g., living for an extended period in a bunker or cave with no natural light or other time cues), we begin to free-run, that is, the usual...
Patient progression and response to immunotherapy are directly influenced by the presence and quality of tumour-infiltrating leukocytes (TILs). In a recentCellpublication, Wang, Zeng et al. demonstrate the functional role of circadian rhythms in altering TIL functionality and quantity, highlighting the ...
We examined the chronically hyperproliferative epidermis of the asebia (ab/ab) mouse for circadian rhythms in cell proliferation and in the rate of DNA synthesis, which is related to S phase duration. the curve for the circadian rhythm in cell proliferation for asebia epidermis was suppressed ...
Circadian rhythms are controlled centrally by the suprachiasmatic nucleus, and are most strongly infuenced by light. Featured A basic role for glia in sleep homeostasis Sleep has restorative properties, but the mechanisms remain largely unknown. A study in Drosophila melanogaster reveals that glia ...
Circadian rhythms are coordinated by the suprachiasmatic nucleus (SCN), which is located in the anterior hypothalamus (Reppert & Weaver, 2001). Because the circadian rhythm is not exactly 24 h, environmental factors such as light, activity, and melatonin are needed to entrain the phase of the ...
Circadian rhythms work via what are basically genetic feedback loops. The researchers found that the TIM protein, along with its partner, the Period (PER) protein, act together to inhibit the genes that are responsible for their own production. With suitable delays between the events of gene ex...
circadian clocks play in nature, how they might have arisen, human health concerns related to clock dysfunction, and mainly focuses on the clockworks found in Drosophila and mice, the two best studied animal model systems for understanding the biochemical and cellular bases of circadian rhythms. Me...
How do nocturnal animals know when it is time to wake up? It's because you—and most other animals—have a kind of internal clock that controls the cycle of the day's biological activities, such as sleeping and waking. These daily biological activities are known ascircadian rhythmsbecause th...
Circadian rhythms are biological cycles that take place every twenty-four hours. Human body temperature, for example, rises and falls in regular twenty-four-hour cycles. Among other behaviors, these cycles make it natural to sleep during the night and to be awake in the daytime. When circumstan...
These changes in phase have been considered to be the chronobiological basis of differences in preferred bed and wake times and age-related changes therein. Whether such differences in phase are associated with changes in the phase relationship between endogenous circadian rhythms and the sleep-wake ...