Circadian rhythm orchestrates the cell cycle of rat renal epithelial cells: a novel mechanism to regulate the cell cycle (Abstract). Kidney Int 68: 1965, 2005.ITO T,YAMATO M,ISHIDA N.CIRCADIAN RHYTHM ORCHESTRATES THE CELL CYCLE OF RAT RENAL EPITHELIAL CELLS:A NOVEL MECHANISM TO REGULATE THE ...
Maintaining a stable circadian rhythm is essential for overall health. Disruption of this rhythm can alter the expression of clock genes and cancer-related genes, and affect many metabolic pathways and factors, thereby affecting the function of the immune system and contributing to the occurrence and...
cell cyclecircadian cycleSome key elements are common to two fundamental periodic regulatory processes; the circadian cycle and the cell cycle. Underlying mechanisms of coordination between the two processes are critical for proper cellular functioning and physiology. Disruption in the mechanisms of one ...
"We suggest that chronic disruption of the normal circadian rhythm tips the balance between tumor-suppressive and tumor-progressive gene expression to favor tumor growth," Sehgal said. "Better understanding the molecular effects of jet lag, shift work, and other sources of chronic disruption may lea...
Rheostatic balance of circadian rhythm and autophagy in metabolism and disease. Front. Cell Dev. Biol. 8, 616434 (2020). Article PubMed PubMed Central Google Scholar Manella, G. et al. Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment....
Cell cycleCancerDNA damage responseTumorigenesisCheckpointBiological rhythmCircadian rhythmThe circadian clock is a fundamental biological process that is pervasive in living organisms. Over the past decade, much has been learned about the molecular mechanism of the mammalian circadian clock. Studies have ...
This review delves into the link between circadian rhythm regulator PERs, disruptions in circadian rhythm, and oncogenesis. We examine the evidence that highlights how dysfunctions in PERs activities initiate cancer development, aid tumor growth, and modify cancer cell metabolism through pathways involved...
Circadian rhythm disruption increased cell proliferation and cell division, which are tightly linked to tumor. Many cancer treatments seek to arrest progression through the cell cycle. The researchers found that the tumor-fighting ability of one drug that arrests cell cycle progression varied with time...
The periods of circadian rhythm of CCA1pro:LUC in cry2 or prr9-1 mutant were longer than those of Col-0 regardless of the blue light intensity tested (Fig. 7a and Supplementary Table 1). Importantly, the circadian period of the cry2 prr9-1 double mutant resembled the prr9-1 single ...
Genes that form a basis for generation and regulation of circadian rhythms by encoding BMAL1, CLOCK, CRY and PER proteins. Amplitude Difference between mesor and peak of the sinusoidal-shaped circadian rhythm. Mesor Mean value of a (circadian) cycle or rhythm. ...