Cell cycleCircadian rhythmImmunofluorescenceIntestinal enteroidsTime course samplingEndogenous circadian clocks play a key role in regulating a vast array of biological processes from cell cycle to metabolism, and disruption of circadian rhythms exacerbates a range of human ailments including cardiovascular, ...
Maintaining a stable circadian rhythm is essential for overall health. Disruption of this rhythm can alter the expression of clock genes and cancer-related genes, and affect many metabolic pathways and factors, thereby affecting the function of the immune system and contributing to the occurrence and...
cell cyclecircadian cycleSome key elements are common to two fundamental periodic regulatory processes; the circadian cycle and the cell cycle. Underlying mechanisms of coordination between the two processes are critical for proper cellular functioning and physiology. Disruption in the mechanisms of one ...
Assuming that periodic control represents the normal circadian rhythm regularly reset by dark-light alternance, and no control (i.e., constant death rates) represents a disrupted circadian clock, we were expecting from the aforementioned experiments on laboratory rodents the converse, i.e., higher ...
Rheostatic balance of circadian rhythm and autophagy in metabolism and disease. Front. Cell Dev. Biol. 8, 616434 (2020). Article PubMed PubMed Central Google Scholar Manella, G. et al. Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment....
Cell cycleCancerDNA damage responseTumorigenesisCheckpointBiological rhythmCircadian rhythmThe circadian clock is a fundamental biological process that is pervasive in living organisms. Over the past decade, much has been learned about the molecular mechanism of the mammalian circadian clock. Studies have ...
Ripperger JA, Schmutz I, Albrecht U (2010) PERsuading nuclear receptors to dance the circadian rhythm. Cell Cycle 9(13):2515-2521Ripperger JA, Schmutz I, Albrecht U. PERsuading nuclear receptors to dance the circadian rhythm. Cell Cycle 2010;9:2515-21....
Circadian rhythm disruption increased cell proliferation and cell division, which are tightly linked to tumor. Many cancer treatments seek to arrest progression through the cell cycle. The researchers found that the tumor-fighting ability of one drug that arrests cell cycle progression varied with time...
This review delves into the link between circadian rhythm regulator PERs, disruptions in circadian rhythm, and oncogenesis. We examine the evidence that highlights how dysfunctions in PERs activities initiate cancer development, aid tumor growth, and modify cancer cell metabolism through pathways involved...
Whenscientistsexaminedthepair'sDNA,theyfoundamutationinagenecalledDEC2,whichgovernscellproductionandcircadianrhythm. 科学家们通过检测这对DNA发现一个叫作DEC2发生了突变,而这个基因正是控制细胞分裂和生理周期的。 article.yeeyan.org 3. NowIthinkthere'samuchbetterawaytoaccomplishthiswithoutthe leastbitofharmdone...