Circadian rhythm and cell cycle are the two main rhythmic and cyclical activities in living organisms,where expression of a series of genes to form a regulatory network. Recent studies have revealed that various clock rhythm factors controlled cell cycle procession by regulating the expression of cell...
Maintaining a stable circadian rhythm is essential for overall health. Disruption of this rhythm can alter the expression of clock genes and cancer-related genes, and affect many metabolic pathways and factors, thereby affecting the function of the immune system and contributing to the occurrence and...
Cycle Res. 3 , 39 .Sigdestad, C.P. & Lesher, S. ( 1972 ) Circadian rhythm in the cell cycle time of the mouse intestinal epithelium . J. interdiscipl. Cycle Res. 3 , 39 .Sigdestad, C.P. and Lesher, S. Circadian rhythm in the cell cycle time of the mouse intestinal ...
Cell division cycles and circadian clocks are major periodic processes in living organisms. Circadian rhythms of cell division have been found in many eukaryotes and some prokaryotes. Circadian clocks gate cell division within discrete time windows. Among bacteria, circadian clocks have been found only ...
Circadian rhythms are involved in regulating almost every kind of physiological activity, including mood regulation, cell cycle control, metabolism, and immune responses. In some pathological conditions, the expression of clock genes also changed. Disruption of circadian rhythm may lead to abnormal cell...
Genes that form a basis for generation and regulation of circadian rhythms by encoding BMAL1, CLOCK, CRY and PER proteins. Amplitude Difference between mesor and peak of the sinusoidal-shaped circadian rhythm. Mesor Mean value of a (circadian) cycle or rhythm. ...
cell cyclecircadian cycleSome key elements are common to two fundamental periodic regulatory processes; the circadian cycle and the cell cycle. Underlying mechanisms of coordination between the two processes are critical for proper cellular functioning and physiology. Disruption in the mechanisms of one ...
"We suggest that chronic disruption of the normal circadian rhythm tips the balance between tumor-suppressive and tumor-progressive gene expression to favor tumor growth," Sehgal said. "Better understanding the molecular effects of jet lag, shift work, and other sources of chronic disruption may lea...
The possible causes of this coupling of the cell cycle phases to the circadian rhythm are discussed. Testing of novel antitumour agents using murine models should take into consideration the temporal difference between murine and human circadian control of proliferation (the peak of DNA synthesis ...
Rheostatic balance of circadian rhythm and autophagy in metabolism and disease. Front. Cell Dev. Biol. 8, 616434 (2020). Article PubMed PubMed Central Google Scholar Manella, G. et al. Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment....