2 A chymotrypsin — like protease from the estrogen-resistant C3H mammary carcinoma increases in vitro the estrogen receptor binding to DNAdoi:10.1016/0022-4731(83)91502-9Pierre Paul BaskevitchElsevier B.V.Journal of Steroid Biochemistry
Chymotrypsin Enhances Soluble Fms-Like Tyrosine Kinase I Production Through Protease-Activated Receptor 2 in Placenta-Derived Immortalized Human Trophoblast CellsChymotrypsin Enhances Soluble Fms-Like Tyrosine Kinase I Production Through Protease-Activated Receptor 2 in Placenta-Derived Immortalized Human Trophobla...
A Survey of SCCA2 Inhibitory Activity A Leu-Ser at the putative reactive center (P1-P1¹), suggested that SCCA2 could inhibit chymotrypsin-like proteinases such as CT, HMC, catG, or PSA (Fig. 1). However, predictions of inhibitory specificity based only on reactive site residues are unre...
The irreversible inhibitor of chymotrypsin-like serine proteases, N-tosyl 鈥揕-phenylalanine chloromethylketone (TPCK), was shown to prevent internucleosomal DNA cleavage caused by inducers of apoptosis. The pro-apoptotic properties of TPCK have been studied less thoroughly. The aim of the present ...
Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to public health. The morbidity is increasing due to lack of SARS-CoV-2 specific drugs. Herein, we have identified potential drugs that target the 3-chymotrypsin like protease (3CLpro...
In addition to the papain-like protease, the 3-chymotrypsin-like protease (3CLpro), also known as the main protease, is important for the posttranslational processing of SARS-CoV-2 polypeptides and the production of 16 non-structural proteins (nsps)5,11,12. The nsps play fundamental roles ...
Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like ... Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3...
CHYMOTRYPSIN-LIKE PROTEASEPROBLEM TO BE SOLVED: To provide a novel protease which is derived from a queen bee larva of honeybee, decomposes royal jelly to obtain functional peptide, and a manufacturing method of a product of proteolysis using the enzyme.YABE TOMIO...
The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of SARS-CoV-2. In this review, we discuss structural relationships and diverse subsites of 3CLpro, shedding ...
Lawrence, Harshani RSebti, Said MOzcan, SevilLawrence HR, Sebti SM, Ozcan S. Proteasome chymotrypsin-like inhibition using PI-1833 analogs. WO2012129564.