The actions of inotropes are mediated largely through α- and β-adrenoceptors, and the lack of receptor specificity of these agents results in a differential effect on receptors at increasing doses, resulting in both inotropic and chronotropic effects. Dobutamine Dobutamine is the most widely used...
In an attempt to determine whether cAMP is involved in the chronotropic and inotropic response produced by glucagon, catecholamines and prostaglandins, the intracellular cAMP levels of beating myocardial cells were determined after pretreatment with the above agents. It was found that the catecholamines ...
Chronotropic agentsRatIn isolated spontaneously beating right and left atria and in electrically driven left atrium from rat, endothelin-1 increased the rate and force of contraction, but significantly decreased the positive chronotropic and inotropic responses to sympathetic nerve stimulation. The decrease...
Immunological modification of chronotropic and inotropic coronary effects of adrenomimetics 来自 Semantic Scholar 喜欢 0 阅读量: 18 作者: S.,G.,Kaz'min,A.,A.,Moibenko,V.,F.,SagachO.,V. 摘要: No Abstract available for this article. 关键词: heart coronary vessels immunological agents ...
Article: Chronotropic and inotropic effects of terikalant on isolated, blood-perfused atrial and ventricular preparations of dogs
alpha- and beta-adrenergic blocking agents on cyclical reductions of blood flow in the partially constricted coronary artery of anesthetized dogs were examined... Y Uchida,N Yoshimoto,S Murao - 《Japanese Heart Journal》 被引量: 201发表: 1978年 Inotropic, chronotropic, and dromotropic effects med...
Mechanisms mediating the positive inotropic and chronotropic changes induced by dopexamine in the anesthetized dog. Mechanisms contributing to the increments in heart rate (HR) and cardiac contractile force (CCF) produced by dopexamine (DPX) were studied in anesthetized dogs. Intravenous infusions of DPX...
Cardiac drugs: Inotropic and chronotropic agentsAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00152193-198710000-00023A H MutnickS FecittB RogersPubMedNursing Management
THE PRESENT INVENTION RELATES TO SUBSTITUTED IMIDAZO[1,2 A][1,8]NAPHTHYRIDINES USEFUL AS POSITIVE INOTROPIC AGENTS. THESE COMPOUNDS CAN BE FORMULATED AND USED AS ORALLY EFFECTIVE POSITIVE INOTROPIC AGENTS WITH NEGATIVE CHRONOTROPIC AND VASODILATORY EFFECTS. THE INVENTION FURTHER RELATES TO PHARMACEUTICAL...
2 All the N6‐R cyclic AMPs except N6‐C14H29 produced positive inotropic effects in papillary muscle. The C5H11, C6H13, C7H15, C8H17 and C9H19 compounds were the most potent as inotropic agents, the potency being lower with compounds having longer or shorter N6‐side chains than ...