The present study was designed to assess the negative chronotropic and inotropic effects of 10 class I antiarrhythmic drugs, using isolated canine blood-perfused sinoatrial node and papillary muscle preparations. Each drug showed negative chronotropic and inotropic effects in a dose-related manner. The ...
chronotropic drugs affect the electrical conduction system of the heart and the nerves while the dromotropic drugs affect the atrioventricular node (AV node)
Digoxin has historically been considered a positive inotropic agent; however, this effect is nearly negligible, particularly compared with the drugs described earlier. However, because pimobendan is often cost prohibitive in horses, it is likely that digoxin will continue to be used for this purpose...
In rat hearts, glucagon induced contractile and chronotropic responses, but only contractility was enhanced by 30 µM IBMX (maximal inotropic effect of glucagon 40 ± 8% vs. 75 ± 10%, in the absence or presence of IBMX, n = 5, P < 0.05; maximal chronotropic ...
The aim was to determine and compare the negative inotropic vs. chronotropic potency of these drugs. The hearts were perfused with oxygenated Krebs-Henseleit buffer at a perfusion pressure of 90 cm H2O. After stabilization, one concentration of each drug was administered for 45 min followed by a...
Cardiac drugs: Inotropic and chronotropic agentsAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00152193-198710000-00023A H MutnickS FecittB RogersPubMedNursing Management
( 1966 ). Inotropic and chronotropic effects of a series of β-adrenergic blocking drugs: some structure-activity relationships . Proc. Soc. exp. Biol. (N.Y.) , 122 , 373 – 379 .Levy, J. V. & Richards, V. ( 1966 ). Inotropic and chronotropic effects of a series of β-...
Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with ...
1. 1. The relationship between the negative inotropic and chronotropic effects of tocainide and 5 other class I antiarrhythmic drugs was evaluated in Langendorff-perfused guinea-pig hearts. 2. 2. All 6 drugs reduced the contractile force (Fc) and the heart rate (HR) of spontaneously beating ...
These subsequently result in increasing the blood pressure and the positive inotropic chronotropic effect in the heart. ACE inhibitors (ACEI) inhibit the activity of ACE in the myocardium, kidney, and vessel wall via decreasing the blood pressure and inhibiting myocardial and vascular hypertrophy. It...