The aim was to determine and compare the negative inotropic vs. chronotropic potency of these drugs. The hearts were perfused with oxygenated Krebs-Henseleit buffer at a perfusion pressure of 90 cm H2O. After stabilization, one concentration of each drug was administered for 45 min followed by a...
Digoxin has historically been considered a positive inotropic agent; however, this effect is nearly negligible, particularly compared with the drugs described earlier. However, because pimobendan is often cost prohibitive in horses, it is likely that digoxin will continue to be used for this purpose...
( 1966 ). Inotropic and chronotropic effects of a series of β-adrenergic blocking drugs: some structure-activity relationships . Proc. Soc. exp. Biol. (N.Y.) , 122 , 373 – 379 .Levy, J. V. & Richards, V. ( 1966 ). Inotropic and chronotropic effects of a series of β-...
Cardiac drugs: Inotropic and chronotropic agentsAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00152193-198710000-00023A H MutnickS FecittB RogersPubMedNursing Management
1. 1. The relationship between the negative inotropic and chronotropic effects of tocainide and 5 other class I antiarrhythmic drugs was evaluated in Langendorff-perfused guinea-pig hearts. 2. 2. All 6 drugs reduced the contractile force (Fc) and the heart rate (HR) of spontaneously beating ...
(typically 5–10mcg/kg/min) is used, aiming to provideinotropic effectswithout significantchronotropic response. If additional information regardingischaemiais required, then doses up to 40mcg/kg/min with additional atropine may be used, in order to reach a target heart rate of 85% of the ...