chronic myeloid leukemia stem cellssignaling pathwaymicroRNAChronic myeloid leukemia (CML) is a myeloproliferative disease of the hematopoietic stem cells, characterized by the presence of the Philadelphia (Ph) chromosome. Although imatinib inhibits the BCR-ABL kinase activity, clinical experiences confirm ...
Chronic myeloid leukemia (CML) is caused byBCRABL1in a cell with the biological potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML leukemia stem cell (LSC). In humans a CML LSC is operationally-defined by ≥1 in vitro or in vivo assays of human leu...
慢性粒细胞白血病(Chronic myeloid leukemia,CML),是一种起源于骨髓造血细胞并侵入血液的癌症。成人白血病中约15%是慢性粒细胞白血病。酪氨酸激酶抑制剂(TKI)有助于改变疾病的预后,与其他癌症治疗相比,副作用更少。然而,TKI只控制了疾病的发展,留下了产生耐药性的可能性。值得庆幸的是,来自广岛大学的研究人员报告说,...
Chronic myeloid leukemia (CML) is a malignant disorder of hematopoiesis resulting from the clonal expansion of a primitive hematopoietic cell. As with all treatments of CML, outcomes are far superior for hematopoietic cell transplantation (HCT) for patients in chronic phase compared to advanced phase...
Targeting DDX3X eliminates leukemia stem cells in chronic myeloid leukemia by blocking NT5DC2 mRNA translation Chen Duan Xiaoying Lin Yanli Jin Research08 Nov 2024 Oncogene P: 1-14 The BIM deletion polymorphism potentiates the survival of leukemia stem and progenitor cells and impairs response to...
Chronic myeloid leukemia (CML) is sustained by a clonally amplified, but still rare population of BCR-ABL+ hematopoietic stem cells (HSCs). Understanding their properties is assuming increasing importance in light of recent evidence that they are innately resistant to BCR-ABL−targeted therapies and...
Chronic myeloid leukemia‐derived exosomes attenuate adipogenesis of adipose derived mesenchymal stem cells via transporting miR‐92a‐3p doi:10.1002/jcp.28732Journal of Cellular PhysiologyWan, ZhuoChen, XutaoGao, XiaotongDong, YanZhao, YingxinWei, MengyingFan, WenYang, GuodongLiu, Li...
Characterization of chronic myeloid leukemia stem cells Although tyrosine kinase inhibitors have redefined the care of chronic myeloid leukemia (CML), these agents have not proved curative, likely due to resista... JM Gerber,Q Lu,J Kowalski,... - 《American Journal of Hematology》 被引量: 135...
Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment . Blood . 2011; 118(20) : 5565–5572Chu S, McDonald T, Lin A, Chakraborty S, Huang Q, Snyder DS, et al. Persistence of leukemia stem cells in chronic myelogenous ...
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest. 2011;121:396–409. doi:10.1172/JCI35721 15. Soverini S, Mancini M, Bavaro L, Cavo M, Martinelli G. Chronic myeloid leukemia: the paradigm of targeting oncogenic ...