Chronic microvascular white matter ischemic change (WMIC) has been shown to be associated with acute brain infarction in the general population. WMIC has also been shown to be an independent predictor of non‐focal neurocognitive changes, generalized seizures, and temporary neurologic dysfunction in ...
Functional and structural abnormalities in the renal microvasculature are important processes contributing to the pathophysiology of ischemic acute kidney injury (AKI). In this study, we examine the contribution of endothelial cell loss via apoptosis on microvascular permeability and rarefaction in a mouse...
Flow cytometry succeeded to detect infiltration of macrophages in the ischemic brain by using tMCAO mice in which ischemic changes were observed globally in re-perfusion area [15]. However, in DOCA-salt rats, localization of vascular damages was sparse, and hence, we performed immunohistochemical ...
Indeed, AD patients show significantly worse cognition when they present chronic microvascular ischemic lesions, such as white matter hyperintensities7,8. One may hypothesize these changes derive from comorbid white matter dysfunction, which may affect brain function by interfering with inter-regional ...
Changes in myocardial ischemic burden following percutaneous coronary intervention of chronic total occlusions. Catheter Cardiovasc Interv 2011;78:337-343. 42. Pujadas S, Pujadas S, Martin V, et al. Improvement of myocardial function and perfusion after successful percutaneous revascularization in patients...
Microvascular blood flow is altered in patients with sepsis. Am J Resp Crit Care. 2002;166:98–104. Article Google Scholar Rozas G, Guerra MJ, Labandeira-Garcia JL. An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism. ...
Microvascular blood flow is altered in patients with sepsis. Am J Resp Crit Care. 2002;166:98–104. Article Google Scholar Rozas G, Guerra MJ, Labandeira-Garcia JL. An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism. ...
(ALX/FPR2). Following myocardial infarction, FPR2-deficient mice had decreased numbers of resolving macrophages and increased numbers of neutrophils at the site of injury, indicating that FPR2 could play an important role in resolution following ischemic injury [191]. Resolvin E1 (RvE1), an ...
A–C Effects of CKD dialysis serum on the iPSC-derived human brain microvascular endothelial cells (ihBMEC) monolayer. Incubation with CKD dialysis serum significantly decreased A TEER, and increased B tracer (sodium fluorescein) permeability across the ihBMEC monolayer 3 days after serum treatment ...
However, whether this aberrant interaction would induce OPC changes is not fully understood. As endothelial dysfunction was detected even before demyelination occurred14,16, it then prompts us to consider the contributing effects of vascular damage to the pathogenesis of ischemic demyelination based on ...