Chronic microvascular white matter ischemic change (WMIC) has been shown to be associated with acute brain infarction in the general population. WMIC has also been shown to be an independent predictor of non-focal neurocognitive changes, generalized seizures, and temporary neurologic dysfunction in ...
MRI: Magnetic resonance imaging SBP: Systolic blood pressure SD: Standard deviation SNAC: Swedish national study on aging and care SPS: Shrunken pore syndrome STRIVE: Standards for reporting vascular changes on neuroimaging SVD: Cerebral small vessel disease SWAN: Susceptibility-weighted angio...
Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse of bilatera
Compared to individuals without DM, those with the condition have a nearly twofold increased risk of developing CKD10, with 40% of those with type 2 DM experiencing diabetic nephropathy, a severe microvascular complication11. The decline in estimated glomerular filtration rate (eGFR) and the onset...
Objective To analyze the correlation between the changes of learning and memory and the progressive degeneration of white matter nerve fibers and pericytes in the corpus callosum and hippocampus of rats with chronic cerebral ischemia, then to explore the mechanism of learning and memory impairment cause...
MRI and histology were performed before and after tissue compression and ischemic loading. Uniaxial loading was applied to the tibialis anterior by means of an indenter, and ischemic loading was accomplished with an inflatable tourniquet. The separate and combined effects of ischemia and deformation ...
A comparative study, with quantitative analysis, was done on the fine structure of the lymphatic capillaries in the subepicardium, myocardium, and subendocardium of the left ventricle from dog hearts. In the three layers, the vesicular s... Y Boucher,S Roberge,PE Roy - 《Microvascular Research...
MRI Visualization of Whole Brain Macro- and Microvascular Remodeling in a Rat Model of Ischemic Stroke: a Pilot Study. Sci Rep. 2020;10:4989. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar...
Knopman34 proposed that microvascular disease or endothelial dysfunction addresses at least one way that CKD causes cognitive decline. In contrast, Gouw et al.35 emphasized that lesions invisible on MRI, such as cortical microinfarcts and tissue changes in the normal-appearing white matter, may ...
changes consistent with CKD-associated cardiomyopathy. In this review we discuss the key drivers of CKD-associated cardiomyopathy and the key role of hypertension in its pathogenesis. We also evaluate existing, as well as developing therapies in the treatment of CKD-associated cardiomyopathy....