matched non-CTO PCI subjects, patients with CTO and an intermediate donor artery stenosis showed a low FFRD with a high frequency of ischemia in the donor artery territory, which was often normalized by successful CTO treatment, thus suggesting recanalization of CTO as a preferred therapeutic ...
Human hepatocyte growth factor (VM202)gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia. Perin EC,Silva GV,Vela DC,et al. Journal of Cardiac Failure . 2011Perin;EC;Silva;GV;Vela;DC;Zheng;Y;Baimbridge;F;Gahremanpour;A;Quan;X;Hahn;W;Kim;J;Wood;K...
Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse of bilatera
introduced an MMP2-sensitive self-assembling peptide (KMP2) hydrogel containing an MMP2-cleavable motif for the treatment of ischemia‒reperfusion (I/R) injury (Fig. 6B)103. Due to enzymatic degradation by MMP2, the network structure of the KMP2 hydrogel was destroyed, and the loaded EVs ...
was remarkably activated, which was responsible for microglia activation and a series of subsequent inflammatory reactions following hypoxic-ischemic injury. The treatment of tolebrutinib restored myelination and ameliorated cognitive impairment in chronic cerebral ischemia, indicating a new therapeutic strategy...
Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis. Am J Physiol Renal Physiol. 2014;306:F970-980. Article CAS PubMed Google Scholar Machiraju P, et al. SS-31 peptide reverses the mitochondrial ...
Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment. ACS Appl Mater Interfaces. 2018;10:30081–30091. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar ...
MicroRNA (miR)-486-5p protects against kidney ischemia–reperfusion (IR) injury in mice, although its long-term effects on the vasculature and development of CKD are unknown. We studied whether miR-486-5p would prevent the AKI to CKD transition in rat, and affect vascular function. Methods:...
Ischemia-reperfusion MCAO: Middle cerebral artery occlusion MMP-9: Matrix metalloproteinase-9 NSC: Neural stem cell NTF: Neurotrophic factor NVU: Neurovascular unit SDF-1α: Stromal cell–derived factor 1-alpha STAIR: Stroke Treatment Academic Industry Roundtable SVZ: Subventricular zone ...
Coronary flow capacity (CFC) is a well investigated physiological index for myocardial ischemia severity that assesses flow limitation arising from combinations of epicardial coronary artery stenosis, diffuse disease, and microvascular dysfunction.1,2,3,4,5,6 Recent studies have highlighted the utility ...