Forty-two patients were evaluated and treated during the past five years at the Union Memorial Hospital Hand Center with the diagnosis of chronic digital ischemia. These patients with this syndrome, manifested by pain, severe cold intolerance and occasional tip ulceration, all were failures of ...
Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse of bilatera
Animal model of chronic cerebral ischemia (CCI): bilateral internal carotid artery ligation (BICAL) Male 6-week-old Wistar rats (200–250 g, body weight) were randomly assigned to different treatment groups. There were four groups in this study: control, BICAL, EPC-CM treatment, and MIF Ab...
Cardiac microcirculatory lesions have been reported in ChHD, but microvascular ischemia may be a consequence of inflammatory mediators, potentiating inflammatory myocardial tissue damage (39). In the acute phase of infection, widespread tissue and blood parasitism triggers a vigorous immune response. ...
We tested the hypothesis that statins would decrease renal injury in renal artery stenosis (RAS) by restoring angiogenesis and attenuating intrarenal microvascular (IMV) remodeling. Single-kidney hemodynamics and function were quantified using electron-beam-computed tomography (CT) in normocholesterolemic ...
was remarkably activated, which was responsible for microglia activation and a series of subsequent inflammatory reactions following hypoxic-ischemic injury. The treatment of tolebrutinib restored myelination and ameliorated cognitive impairment in chronic cerebral ischemia, indicating a new therapeutic strategy...
matched non-CTO PCI subjects, patients with CTO and an intermediate donor artery stenosis showed a low FFRD with a high frequency of ischemia in the donor artery territory, which was often normalized by successful CTO treatment, thus suggesting recanalization of CTO as a preferred therapeutic ...
Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia Faseb JournalChade AR, Zhu X, Mushin OP, Napoli C, Lerman A, Lerman LO. Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic... AR Chade,X Zhu,OP Mushin,... - 《Faseb ...
Two years after stent implantation, the patient was well without ischemia or thrombosis. APS should be considered a potential cause of serious coronary disease in young adults. <Learning objective: Antiphospholipid syndrome (APS) should be considered a potential cause of serious coronary disease in ...
While not wishing to be bound by theory the present inventors believe that chronic or recalcitrant skin damage sites, far from being inactive, are highly active tissues. It is believed that cycles of ischaemia and reperfusion or peripheral venous hypertension lead to recurring microvascular damage. ...