Mild traumatic brain injury (mTBI) can result in lasting brain damage that is often too subtle to detect by qualitative visual inspection on conventional MR imaging. Although a number of FDA-cleared MR neuroimaging tools have demonstrated changes associated with mTBI, they are still under-utilized ...
Longitudinal clinical studies on contact sport athletes with repeated concussions—combining imaging (MRI and both amyloid and tau PET) and fluid biomarkers reflecting different aspects of CTE pathophysiology (tau pathology, neuronal degeneration, gliosis, and amyloid deposition)—are needed. These ...
The histological examination of the stimulated tissue revealed a fibrillary gliosis due to the trauma caused by the insertion of the electrodes, but no signs of additional tissue damage due to electrical stimulation or chronic mechanical irritation. The results indicate that it is possible to ...
Chronic traumatic encephalopathy (CTE) is a perplexing condition characterized by a broad and diverse range of neuropathology and psychopathology. While there are no agreed upon or validated clinical criteria for CTE, case series of CTE have described a
Harrison Martland was the first to mention "perivascular microhemorrhages" that progressively evolved into "replacement gliosis," resulting in punch drunk syndrome. Abram Bowman and Karl Blau then coined the term CTE to better characterize the condition. N. Corsellis subsequently identified neurofibrill...
although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroin fl ammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased.ese longterm abnormalities...
and accurate quantitative evidence suggesting that the total number of microglia in the hippocampus is altered in CUS model rats after running exercise. More importantly, our results indicate that hippocampal microglia might be structural targets for the ameliorative effects of running exercise on ...
In addition, it has been reported that MSCs secrete cytokines and growth factors that promote autocrine and paracrine effects, such as immunosuppression, inhibition of gliosis and apoptosis, enhanced angiogenesis, axon sorting and myelination [20, 21]. In previous studies, we have established a ...
‘increased cell membrane turnover due reparative gliosis’ [310]. In addition, Puriet al. [311] established a significant choline/creatine signal in the occipital cortex of patients with ME/CFS. In children with ME/CFS, significant increases in the choline/creatine ratio as measured by MRS ...
We aimed to evaluate whether white and gray matter microstructure changes observed with magnetic resonance imaging (MRI)-based diffusion tensor imaging (DTI) can be used to reflect the progression of chronic brain trauma. The MRI-DTI parameters, neuropat