Other chromosomes such as −11q may also have immune evasion functions, while −22q may have both pro-proliferative and immune evasion functions. Driver gene mutations are not required for CNA selection During in vitro evolution, acquired non-synonymous single nucleotide variants (SNVs) and ...
Compared to autosomes, it is relatively easy to assign genes to the X chromosome (hence, ‘X-linked’), because females have two XX chromosomes, while males have a single X chromosome and a single Y chromosome, which bears the testis-determining gene and dictates that a Y-bearing individual...
dCircos plot of gene features at 500-kb intervals across the 12 chromosomes of the two haplotype genomes of Y476. The GC content, gene density, TE density, and SNPs and InDels between the Y476 and Nip genomes are shown (from the outer ring to the inner ring). The outer black track r...
Fig. 1.Diagram of a typical BAC vector. This vector is a compilation of the original pBAC108L (Shizuya et al., 1992), pBACe3.6 (Frengen et al., 1999) and pCC1BAC™ (Epicentre Technologies). The cam® gene encodes chloramphenicol antibiotic resistance. The repE, parA, parB...
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours EWING'S sarcoma and related subtypes of primitive neuroectodermal tumours share a recurrent and specific t(ll;22) (q24;q12) chromosome translocation 1鈥 8 ,... O Delattre,J Zucman,B Plougastel,......
PROBLEM TO BE SOLVED: To provide a method for non-invasively determining an aneuploidy Y chromosome abnormality in a maternal sample by detecting and determining the relative contribution of the gene sequence of the Y chromosome in the maternal sample. SOLUTION: In the maternal sample, the locus ...
The ganA gene from Bacillus subtilis encoding a β-galactosidase for degradation of the galactomannan was integrated in different loci of the B. subtilis chromosome employing the CRISPR/Cas9 system. Hereby a total of five copies of ganA cassettes in which the ganA gene was fused with the glucitol...
single-copy, multiple-copy, unique, and other orthologs in the 17 plant species.cVenn diagram represents the shared and unique gene families among five closely related magnoliids (C. praecox,C. kanehirae,L. chinense,P. nigrum, andC. chinensis). Each number represents the number of gene ...
HLA typing performance.aRead alignment forHiseq X Ten/PCR-free (purple),Nextseq 500/PCR-based (blue), MGISEQ-2000 (yellow), andONT PromethION(green) at exons 2 and 3 (G-group) of the HLA-A gene representation of the in silico chromosome. Immune repertoire analysis.bThe schematic figure...
However, gains of whole chromosomes 22 also contributed to the increased dosage of 22q11.2 which may point to a role of genes of chromosome 22 in addition to the BCR-ABL gene in the development of Ph-positive ALL. Gains at chromosome 1 and 8 accumulating at the entire long arm and also...