Using single molecule sequencing (PacBio), optical mapping, and manual curation, we assembled theB. malayigenome into five chromosomes, with only eight gaps (Supplementary Table1). With an N50 of 14.2 Mb, this improves substantially on the previous assemblies6and is one of very few parasiti...
a Ribbon diagram demonstrating conserved chromosomal synteny and large-scale segmental collinearity (semi-transparent gray ribbons) between Dioscorea alata (black horizontal bars), D. rotundata (gold), and D. zingiberensis (cyan) one-to-one orthologous gene pairs. Only D. rotundata sequences with ...
Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions. The word chromosome comes from the Greek χρῶμα (chroma, color) and σῶμα (soma, body) due to their property of being very strongly stained by particular dyes. Diagram of a ...
Chromosome structure refers to the arrangement of DNA double-helix backbone in a chromosome, where it extends uninterrupted from one end to the other, including the centromere. In the cell cycle, the chromosome duplicates and consists of two identical chromatids in the G2 stage. A break in the...
(including large insertions, deletions, duplications, inversions, and translocations), (iii) HLA genes, and (iv) immune receptor genes.bThe schematic diagram illustrates the use of synthetic DNA controls (sequins) and the in silico chromosome during the NGS workflow (upper panel). The range of ...
“Bacterial artificial chromosome(BAC) clones of known location along the physical map will be sequenced to 6X coverage, and integrated with the available sequence information obtained through prior sequencing ofexpressed sequence tags(ESTs),transposoninsertion sites, gene-enriched genomic DNA and...
In mammalian meiotic prophase, homologous chromosome recognition is aided by formation and repair of programmed DNA double-strand breaks (DSBs). Subsequently, stable associations form through homologous chromosome synapsis. In male mouse meiosis, the lar
Diagram showing the maximum numbers of gains and losses at each chromosome. Full size image Figure 3 Distribution of the quantitative changes of each single chromosome. Graphical presentation of the results of the automated analysis of the SCCN strings of the karyotypes of 94 Ph positive ALL ...
and to acquire novel male-benefit genes on the Y [1–7]. These opposing effects lead to a heterogeneous structure of Y chromosomal DNA, with functional genes (often male specific, sometimes highly amplified) set among a sea of degenerate pseudogenes, repetitive sequence, and parasitic transposable...
In the diagram of Fig. I the markers have been plotted, their length in thousandths of the total length of the autosomal haploid set on the abscissa, and their arm ratio on the ordinate, the latter in a logarithmic scale. The diagrams show clearly that there is considerable agreement ...