Chromatin is a flexibly joined chain of nucleosomes that exists inside the nucleus of eukaryotic cells and has been described as a 'bead on a string'. Chromatin organization strengthens DNA for mechanically stressful processes like mitosis, helps protect DNA from damage and is important in the con...
Laskey R.A, Harland R.M, Earnshaw W.C, Dingwall C. Chromatin assembly and the co-ordination of DNA replication in the eukaryotic chromosome. In: Schweiger H, editor. International cell biology. Springer; Heidelberg: 1981. pp. 162–167....
Chromatin is a packaging material for DNA. If not packed well, it can tangle around itself or get damaged duringcell division. The size of cells is in micrometers and a DNA can be as long as 3 meters. In order to fit such a lengthy structure into a micrometer cell, tight packing is...
Comparing the length of metaphase chromosomes to that of naked DNA, the packing ratio of DNA in metaphase chromosomes is approximately 10,000:1 (depending on the chromosome). This can be thought of as akin to taking a rope as long as a football field and compacting it down to less than ...
To understand how interphase chromatin is organized in eukaryotic cell nuclei, it is essential to understand what kind of interactions influence the nuclear architecture and to what extent. Using a mesoscale model that incorporates chromatin–chromatin interactions as well as binding of chromatin to the...
Notably, envi- ronmental changes can alter the 3D organization of the eukaryotic chromatin, as in a report in which Arabidopsis exposure to heat stress resulted in chromatin reorganiza- tion related to the activation of transposons [21]. Simi- larly, the cold treatment of rice can increase ...
Role Of Chromatin In Cell Division Chromatin is a type of genetic material composed ofDNAand proteins. It helps to pack the DNA into a small voluminous structure that can be contained within the nucleus. It condenses to form the chromosomes during eukaryotic cell division. ...
To understand howinterphasechromatinis organized in eukaryotic cell nuclei, it is essential to understand what kind of interactions influence the nuclear architecture and to what extent. Using a mesoscale model that incorporates chromatin–chromatin interactions as well as binding of chromatin to thenuclea...
Several approximations have to be made to model the chromatin fiber as a homopolymer, i.e., a polymer with all monomers interacting in the same way, having the same size and uniform flexibility along the chain. As a first approximation, eukaryotic chromatin can be considered as a polymer fibe...
Physical access to DNA is a highly dynamic property of chromatin that plays an essential role in establishing and maintaining cellular identity. The organization of accessible chromatin across the genome reflects a network of permissible physical interactions through which enhancers, promoters, insulators ...