In the past the histones were generally considered the repressors of the transcriptional and replicative processes. Present opinion stresses their structural role in organizing the DNA molecules in chromatin fibres. The association of histones with DNA is not random and leads to an orderly, repetitive...
and thus the structure of continuous chromatin fibres, which has not been possible in previous efforts31,32,35,42. Our data show that most nucleosomes are connected by straight linker DNA, forming a flexible, relaxed zigzag pattern, substantiated by both direct visualizations of individual nucleosom...
the relevant bead dimensions, elastic properties, and the nature of inter-bead potentials are unknown. Using nucleosome-resolution contact probability (Micro-C) data, we systematically coarse-grain chromatin and predict quantities
Open and closed domains in the mouse genome are configured as 10-nm chromatin fibres EMBO Rep, 13 (2012), pp. 992-996 Google Scholar 36 A. Visvanathan, K. Ahmed, L. Even-Faitelson, D. Lleres, D.P. Bazett-Jones, A.I. Lamond Modulation of higher order chromatin conformation in mamma...
Cellular processes occur when chromatin fibres become less condensed, providing areas of open chromatin which allow transcription to proceed. Areas of open chromatin are associated with active DNA regulatory elements, including promoters, enhancers, silencers, and insulators. Chromatin accessibility is also...
One significant implication of this study concerns the techniques used for the experimental observation of the fibres: those most commonly used today have inadequate resolution to be able to observe this type of reorganization, so we aim to develop new methodologies (like the FISH technique based on...
One significant implication of this study concerns the techniques used for the experimental observation of the fibres: those most commonly used today have inadequate resolution to be able to observe this type of reorganization, so we aim to develop new methodologies (like the FISH technique based on...
Open and closed domains in the mouse genome are configured as 10-nm chromatin fibres. EMBO Rep. 2012, 13, 992–996. 4. Joti, Y.; Hikima, T.; Nishino, Y.; Kamada, F.; Hihara, S.; Takata, H.; Ishikawa, T.; Maeshima, K. Chromosomes without a 30-nm chromatin fiber. Nucleus ...
The levels of BAZ2A are upregu- lated and associated with poor prognosis and recurrence in various tumors, such as prostate cancer [28]. Interest- ingly, high levels of BAZ2A correlate with the deletion of the PTEN gene in primary prostate cancer, which can be an indicator of poor ...
Mitotic metaphase chromosomes with two chromatids are composed of two chromatin fibres, each of which is a complex of one DNA double strand and histone proteins1 making up the nucleosome, the fundamental structure of the 11-nm nucleosome fibre2. The nucleosome has a cylindrical shape of 6-nm ...