Based on Median Effect Equation (Chou), Combination Index Theorem and Dose Reduction Index Equation (Chou-Talalay), we tested six binary combinations and four ternary ones to define and quantify their pharmaco-dynamic interactions (synergism, antagonism or additivity). The highest-to-lowest order of...
The Chou-Talalay method for drug combination is based on the median-effect equation, derived from the mass-action law principle, which is the unified theory that provides the common link between single entity and multiple entities, and first order and higher order dynamics. This general equation ...