European Network for Oxysterol Research 1 Cholesterol metabolism Cholesterol, together with phospholipids, is a key structural element of the lipid bilayer. It is the precursor to bile acids, steroid hormones an
Lipoproteins transport triglycerides to the cell membrane. There, they are broken down into fatty acids and metabolized to make adenosine triphosphate (ATP). Cells use ATP for energy. Triglycerides will be high in individuals with high insulin levels, insulin resistance, and infatty liverdisease. Id...
Cholesterol is not metabolized for energy. It is removed from the body via desquamating cells and by the excretion of cholesterol and its products, including bile acids and steroid hormone catabolites. A relatively constant level is maintained in the body by controlling the rate of biosynthesis, ...
Previous studies have proved that different cellular uptake mechanisms can lead to different uptake efficiencies, and fusion, compared with the high-energy-dependent endocytosis pathway, is a low energy cost pathway, which could facilitate cellular uptake38,39. We thus assumed that the cholesterol-enri...
The National Health Service (NHS) provides assistance for eligible patients under Medicare, making it highly accessible. The prevalence of cataracts increases with age, making this procedure particularly relevant for the elderly population, who often experience a decline in their quality of life due ...
These data suggest that excessive cholesterol intake can trigger inflammatory responses and ER stress, leading to pancreatic damage and reduced glucose utili- zation, which provides a novel insight into the pathogen- esis of diabetes. Acknowledgments: Not applicable. Funding information: Not applicable....
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing facto
Liver X receptor-α (LXRα) regulates cellular cholesterol abundance and potently activates hepatic lipogenesis. Here we show that at least 1 in 450 people in the UK Biobank carry functionally impaired mutations in LXRα, which is associated with biochemical evidence of hepatic dysfunction. On a ...
cellular membranes and lipoproteins as well as between different classes of lipoproteins; (iii) that deuterium uptake into free cholesterol of the major pool of cholesterol reflecting synthesis; and (iv) that synthesis of cholesterol in the major pool provides a reasonable measurement of total ...
3A). Recently, it was suggested that neurons might depend entirely on cholesterol from extra-neuronal sources as a way of conserving the cost of sterol synthesis, allowing the neuron to focus its energy resources on its specialized function of generating electrical activity (55). Supporting a ...