Interleukin-27 (IL-27) is an immunoregulatory cytokine whose essential function is to limit immune responses. We found that the gene encoding cholesterol 25-hydroxylase (Ch25h) was induced in CD4+T cells by IL-27, enhanced by transforming growth factor–β (TGF-β), and antagonized by T-be...
Although previous studies suggested that high concentrations of 7-DHC are cytotoxic to developing neurons by favouring lipid peroxidation3, we now show that 7-DHC accumulation confers a robust prosurvival function in cancer cells. Because of its far superior reactivity towards peroxyl radicals, 7-DHC...
study cholesterol behavior and function in live cells and organisms. Introduction Biological membranes are composed of different types of lipids, phospholipids, sphingolipids and cholesterol, and integral as well as associated proteins. They can adopt a vast array of configurations and are highly ...
Dietary fiber is found exclusively in plant foods. It serves as the structural framework in plants and is one of the most abundant compounds in nature. Fiber is the part of the plant that is not broken down in the intestines by human digestive enzymes. Because it is not digested, fiber is...
Cell Metabolism, Volume 30, Issue 1, 2 July 2019, Pages 12-13 Elodie Picarda, Xiaoxin Ren, Xingxing ZangView PDFHighlights Summary Tumor-infiltrating T cells often lose their effector function; however, the mechanisms are incompletely understood. We report that cholesterol in the tumor microenviro...
Lipid bilayers form the basis of cell membranes and the phase behaviour of the membrane has been linked to proper cell function. Model membranes composed of relatively simple mixtures of phospholipids and cholesterol can already exhibit complex phase behaviour. Specifically, liquid ordered–liquid disorde...
Langhorst, M.F., Reuter, A., and Stuermer, C.A., 2005, Scaffolding microdomains and beyond: the function of reggie/flotillin proteins.Cell Mol. Life Sci.62:2228–2240. ArticleCASPubMedGoogle Scholar Ledoux, J., Werner, M.E., Brayden, J.E., and Nelson, M.T., 2006, Calcium-activat...
Cholesterol, an abundant lipid in both secretory vesicles and cell plasma membrane can affect this process. In this study, amperometric recordings of vesicular dopamine release from two different artificial cell models created from a giant unilamellar liposome and a bleb cell plasma membrane, show ...
Given that disrupting ion homeostasis across the cellular membrane could result in cell death31,52,88,89,90, it is expected that these hole-punching channels might exert toxicity on cancer cells. In this regard, we applied a standard cell viability assay to evaluate the anticancer activities of...
These studies provide evidence for a role of macrophage SR-BI expression in the pathogenesis of atherosclerosis. Besides the function of SR-BI in cellular lipid metabolism, the expression of this receptor has a substantial impact on the composition of HDL particles in plasma (6). HDL from SR-...