目的探讨胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,CYP7A1)基因多态性与阿尔茨海默病(AD)的关系。 更多例句>> 3) CYP7A1 胆固醇-7α羟化酶 4) Cholesterol 7α-hydroxylase 胆固醇7α羟化酶 例句>> 5) CYP7A1 gene 胆固醇7α-羟化酶基因 ...
7-keto Cholesterol is a bioactive sterol that can affect cholesterol homeostasis, membrane properties and cell survival.{26766,26765} It strongly inhibits cytochrome P450 7A1 (CYP7A1), the cholesterol 7α-hydroxylase, with an IC50 = ~ 1 µM.{26765} 7-keto Cholesterol can be produced by oxi...
This study was undertaken to determine the effect of transient overexpression of hepatic cholesterol 7alpha-hydroxylase on low density lipoprotein (LDL) cholesterol transport in mice lacking LDL receptors (LDL receptor-/-). Primary overexpression of hepatic 7alpha-hydroxylase in LDL receptor-/- mice ...
This demonstrated that primary overexpression of hepatic 7α-hydroxylase markedly lowered plasma LDL concentrations in animals fed control or Western-type diets. Notably, the reduction in plasma LDL levels was due, in large part, to a decrease in the rate of LDL cholesterol entry into the plasma...
Endotoxin (LPS) and cytokines increase cholesterol synthesis and the secretion of lipoproteins by the liver in rodents resulting in hypercholesterolemia. Cholesterol 7 alpha-hydroxylase (CAH) is the rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver, the major regulated ...
2000. Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. J Lipid Res... M Marrapodi,John Chiang - 《Jlr Papers in Press》 被引量: 143发表: 2000年 The inhibition of the human cholesterol 7α‐hydroxylase ge...
The cholesterol 7α-hydroxylase gene (CYP7A) is transcriptionally regulated by a number of factors, including hormones, bile acids, and diurnal rhythm. Previous studies have identified a region from nucleotides (nt) −74 to −55 of the rat CYP7A promoter that enhanced bile acid repression ...
7-keto Cholesterol is a bioactive sterol that can affect cholesterol homeostasis, membrane properties and cell survival.{26766,26765} It strongly inhibits cytochrome P450 7A1 (CYP7A1), the cholesterol 7α-hydroxylase, with an IC50 = ~ 1 µM.{26765} 7-keto Cholesterol can be produced by oxi...
7-keto Cholesterol is a bioactive sterol that can affect cholesterol homeostasis, membrane properties and cell survival.{26766,26765} It strongly inhibits cytochrome P450 7A1 (CYP7A1), the cholesterol 7α-hydroxylase, with an IC50 = ~ 1 µM.{26765} 7-keto Cholesterol can be produced by oxi...