Cholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known. The author found that CH25H transcript is expressed mostly in glomerular and peritubular endothelial cells and tha...
Approximately 1 g of cholesterol is eliminated from the body every day in the form of bile acids. There are two major pathways in bile acid synthesis: the neutral pathway is initiated by the rate-limiting enzyme, cholesterol 7α-hydroxylase which is mainly expressed in hepatocytes while the aci...
Cholesterol 25-hydroxylase (CH25H) is an enzyme that catalyses the oxidation of cholesterol to form the soluble product 25-hydroxycholesterol (25-HC). 25-HC is an oxysterol that can play an important role in different biological processes7,8. Studies of 25-HC have identified it as an innate...
Cholesterol25-hydroxylase (CH25H) 25-hydroxycholesterol (25HC) Encephalomyocarditis virus (EMCV) 3D protein 1. Introduction Encephalomyocarditis virus (EMCV) infects many mammalian species, causing pathologies such as encephalitis, myocarditis, neurologic diseases, diabetes and reproductive disorders (Carocci...
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH...
Novikova, Ludmila A.Springer USMolecular BiotechnologyEfimova VS, Isaeva LV, Makeeva DS, Rubtsov MA, Novikova LA. Expression of cholesterol hydroxylase/lyase system proteins in yeast S. cerevisiae cells as a self-processing polyprotein. Mol Biotechnol. 2017;59:394-406....
Acyltransferase 1 CSF: Cerebrospinal fluid 24-OHC: 24-Hydroxycholesterol Aβ: Amyloid-β ACID: APP intracellular domain APP: Amyloid precursor protein 27-OHC: 27-Hydroxylcholesterol CYP27A1: Sterol 27-hydroxylase RAS: Renin–angiotensin system PLTP: Phospholipid transporters SNpc: Substa...
We also measured other enzymatically generated oxysterols including 7α-hydroxycholesterol, 4β-hydroxycholesterol and 25-hydroxycholesterol catalyzed by CYP7A1, CYP3A4 and cholesterol 25-hydroxylase respectively. These enzymes oxidize cholesterol for various purposes including cholesterol elimination. Even ...
Alzheimer's disease amyloid precursor protein amyloid-β peptide 24S-cholesterol hydroxylase 24-hydroxycholesterol apolipoprotein E Cholesterol is a major lipid component of eucaryotic plasma membranes, imparting both flexibility and stability, and it is the precursor for the biosynthesis of bile acids as ...
Fourthly, it would be interesting to determine whether the antidiabetic effect of silicon is mediated by other specific pathways from FXR, such as the activation of the FXR/Takeda G protein-coupled receptor 5 (TGR5)/glucagon-like peptide-1 (GLP1) pathway, since BAs activate TGR5 in intestinal...