Kruppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation 2017; 136:1315-30.Li Z, Martin M, Zhang J, et al. Kruppel-like factor 4 regulation of cholesterol-25-hydroxylase...
Cholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known. The author found that CH25H transcript is expressed mostly in glomerular and peritubular endothelial cells and tha...
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH...
Cholesterol 25-hydroxylase (CH25H) is an enzyme that catalyses the oxidation of cholesterol to form the soluble product 25-hydroxycholesterol (25-HC). 25-HC is an oxysterol that can play an important role in different biological processes7,8. Studies of 25-HC have identified it as an innate...
We also measured other enzymatically generated oxysterols including 7α-hydroxycholesterol, 4β-hydroxycholesterol and 25-hydroxycholesterol catalyzed by CYP7A1, CYP3A4 and cholesterol 25-hydroxylase respectively. These enzymes oxidize cholesterol for various purposes including cholesterol elimination. Even ...
Cholesterol25-hydroxylase (CH25H) 25-hydroxycholesterol (25HC) Encephalomyocarditis virus (EMCV) 3D protein 1. Introduction Encephalomyocarditis virus (EMCV) infects many mammalian species, causing pathologies such as encephalitis, myocarditis, neurologic diseases, diabetes and reproductive disorders (Carocci...
There are two major pathways in bile acid synthesis: the neutral pathway is initiated by the rate-limiting enzyme, cholesterol 7α-hydroxylase which is mainly expressed in hepatocytes while the acidic pathway begins with the sterol 27-hydroxylase and is responsible for approximately 10% of bile ...
Synthesis of the different Aβ peptides were performed on a Gyros-Protein Technologies, Inc., prelude synthesizer at a 25-µmol scale using a tenfold excess of Fmoc-amino acid relative to the preloaded Fmoc-Gly-wang-LLresin (0.33 mmol/g) or Fmoc-Ala-wang-LLresin (0.33 mmol/g). Fmoc...
25-Hydroxycholesterol suppresses gilteritinib increased cholesterol in lung cancer cells via inhibiting cholesterol synthesis and accelerating cholesterol efflux 25-Hydroxycholesterol (25HC), a cholesterol metabolite, is an oxysterol derived from cholesterol by cholesterol 25-hydroxylase (CH25H). 25HC is ...
Bottom left: Astrocytes are the major producers of cholesterol in the CNS and HMG-CoA reductase mediates conversion of acetyl-CoA to cholesterol. Apolipoprotein E (apoE), the major protein constituent of the high-density lipoprotein (HDL)-like complexes that transport cholesterol from astrocytes throu...