如果大家遇到利用ChIP-seq研究DNA甲基化的文献可以与小远一起讨论交流哦！References：Egelhofer T A, Minoda A, Klugman S, et al. An assessment of histone-modification antibody quality[J]. Nature structural & molecular biology, 2011, 18(1): 91-93.Huang H, Sabari B R, Garcia B A, et al....
ChIP-seqHistone modificationsChromatin stateSingle-cell analysisQuality assessmentMachine learningChromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in epigenomic research. Genome-wide analysis of histone modifications, such as enhancer analysis and genome-wide chromatin state ...
以下就是ChIP-seq的几个主要应用方向： 1、ChIP-seq可以研究组蛋白的修饰情况，以剖析表观遗传特征和生物学功能；2、 ChIP-seq可用来研究转录因子结合位点，解析该转录因子作用的通路信息；3、ChIP-seq技术可得到核小体的定位图谱，核小体定位在转录调控，DNA复制和修复等多种细胞过程中并起着重要作用；4、ChIP-s...
1. Zang,Chongzhi; Schones, Dustin E.; Zeng, Chen;et al.A clustering approach foridentification of enriched domains from histone modification ChIP-Seq data.Bioinformatics, 2009, 25(15): 1952-1958 摘要: Background: Histone modifications a...
ChIP-seq reveals broad roles of SARD1 and CBP60g in regulating plant immunity[J]. Nature communications, 2015, 6(1): 1-12. Torres-Perez J V, Irfan J, Febrianto M R, et al. Histone post-translational modifications as potential therapeutic targets for pain management[J]. Trends in ...
Luo C, Lam E. Quantitatively profiling genome-wide patterns of histone modifications in Arabidopsis thaliana using ChIP-seq[M]//Plant Epigenetics and Epigenomics. Humana Press, Totowa, NJ, 2014: 177-193. Luo M, Cheng K, Xu Y, et al. Plant responses to abiotic stress regulated by histone ...
Quantitatively profiling genome-wide patterns of histone modifications in Arabidopsis thaliana using ChIP-seq[M]//Plant Epigenetics and Epigenomics. Humana Press, Totowa, NJ, 2014: 177-193. Luo M, Cheng K, Xu Y, et al. Plant responses to abiotic stress regulated by histone deacetylases[J]. ...
Histone modifications (HMs) are post-translational modifications of the nucleosome. Studying the presence or absence of these modifications in genomic regions is a central topic in modern epigenetics. HMs regulate various biological processes by overwriting the DNA-inscribed code. Experimental evidence ...
Sun T, Zhang Y, Li Y, et al. ChIP-seq reveals broad roles of SARD1 and CBP60g in regulating plant immunity[J]. Nature communications, 2015, 6(1): 1-12. Torres-Perez J V, Irfan J, Febrianto M R, et al. Histone post-translational modifications as potential therapeutic targets for ...
ChIP-Seq是近年来新兴的将ChIP与新一代测序技术相结合,在全基因s组范围内分析转录因子结合位点(transcription factor binding sites,TFBS)、组蛋白修饰(histone modification)、核小体定位(nucleosome positioning)和DNA 甲基化(DNA methylation)的高通量方法[2-4]。其中ChIP是全基因组范围内识别DNA与蛋白质体内相互作用...