洛杉矶Cedars-Sinai Medical Center杨毅辉和Ju Dong Yang博士团队、伦敦Imperial College London,David J. Pinato教授团队合作在JAMA Oncology发表“Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis”(图1)。
上述研究成果以“ImmuneCheckpointInhibitorsforChild-PughClassBAdvancedHepatocellularCarcinoma:ASystematicReviewandMeta-Analysis”为题在美国医学会肿瘤学期刊《JAMAOncology》发表交大二附院为第一作者和通讯作者单位,内科学传染病专业博士生谢恩睿为第一作者,杨毅辉博士和BernhardScheiner博士为共同第一作者;感染科纪泛扑为末...
Child-Pugh分级系统是评估肝硬化患者肝功能的最常用方法之一。它评估了五个关键的临床参数-血清胆红素水平、血清白蛋白水平、凝血酶原时间、腹水和肝性脑病。 The Child-Pugh classification divides patients into three classes - class A, B, and C, based on the total score obtained from the five parameters...
Sorafenib in patients with Child-Pugh class A and B advanced hepatocellular carcinoma:a prospective feasibility analysis. Pressiani T,Boni C,Rimassa L,Labianca R,Fagiuoli S,Salvagni S,Ferrari D,Cortesi E,Porta C,Mucciarini C,Latini L,Carnaghi C,Banzi M,Fanello S,De Giorgio M,Lutman FR,...
(AUC)wasderivedtoassessthe diagnosticvalue,andthebestcut offvaluewascalculatedbasedontheYordonindex.Results:ComparedwithChild PughA +B grade patients,WBC,AST,TBil,PT,andINRlevelsweresignificantlyhigherinChild PughclassCpatients,whileRBC,HGB,PLT,andAlbwere lowerthantheformer;TC,TG,HDL C,andLDL C...
moderate or severe hepatic impairment (Child-Pugh Class A, B or C); however safety and efficacy of a SOF-based regimen have not been established in patients with decompensated cirrhosis. SOF的药量调整没有为患者需要与温和,适度或者严厉肝损伤 (孩子Pugh类A, B或者C); 然而基于SOF的养生之道的安全...
一般不说patients with Child-Pugh (class) C,而是patients with Child-Pugh (class) C cirrhosis或者Child-Pugh (class) C patients;总之,Child-Pugh (class) C在这里相当于定语。 在英文中如果要表达“客观反映了……”,这个“客观”一般可以考虑译成accurately,而不是objectively(有很重的中式英语味道)。编辑...
摘译自:Xie E, Yeo YH, Scheiner B, et al. Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. JAMA Oncol. 2023 Aug 24. 报道/临床肝胆病杂志 扩展阅读Read more 学术前沿|eBioMedicine:升高的C反应蛋白介导肝-脑轴 ...
一般不说patients with Child-Pugh (class) C,而是patients with Child-Pugh (class) C cirrhosis或者Child-Pugh (class) C patients;总之,Child-Pugh (class) C在这里相当于定语。 在英文中如果要表达“客观反映了……”,这个“客观”一般可以考虑译...
表1. ICIs治疗Child-Pugh B级肝功能的晚期HCC患者的安全性[1] 注:IR:发生率;irAE:免疫治疗相关不良事件;NA:未获得;OR:比值比;trAE:治疗相关不良事件。a:IR来自Child-Pugh B和Child-Pugh A组;OR来自Child-Pugh B vs. Child-Pugh A。 总体而言,该项研究结果表明:Child-Pugh B级晚期HCC患者使用ICIs治疗尽管...