Over the past 20 years, chemotherapy for malignant brain tumours has found a wider application. Particularly in the malignant supratentorial gliomas of adults, large systematic randomized studies have attempted to establish the aims, value and relative risks of surgery, radiotherapy and chemotherapy. At...
The use of chemotherapeutic drugs in the therapy of brain tumours is obviously hindered by the blood brain barrier (bbb). The application of a chemotherapeutic drug directly into the brain tumour is often practised, but without the expec... E.A. Neuwelt M.D. - 《International Journal of De...
The combination of chemotherapy and irradiation for the treatment of malignant intracerebral tumours is increasing, and survival times longer than those after monotherapy are reported. The suitability of simultaneous radio-chemotherapy using BCNU-Bleomycin, a regimen in which has been followed 38 patients...
"Temozolomide is used as part of the standard of care for fitter people with grade 4 gliomas, the highest grade and most aggressive type of brain tumour. What we've been trying to find out is whether temozolomide improves survival in people who have non-codeleted grade 3 tumours." Grades ...
Researchers atPanTher Therapeuticsare developing a novel drug-eluting device for targeting chemotherapeutics to solid tumours. The cremaphor formulation of paclitaxel has dose limiting toxicity which prevent its use for pancreatic cancer. Paclitaxel’s toxicity like the majority of chemotherapeutics stems fro...
Enhancement of chemotherapy and hyperthermia in an experimental brain tumour model by manipulation of tumour microenvironment and drug delivery Summary The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low pH reduces the uptake...
In a new study published inClinical Cancer Research, scientists found a significant survival benefit in rat models withbrain tumourswhen a combination of two chemotherapy drugs, (etoposide and temozolomide), were delivered using abiodegradable polymercalled PLGA/PEG. ...
Pre-treatment and post-treatment CT scans of the brain in 94 patients with brain tumors have been reviewed. The CT scan changes of the brain following chemotherapy, radiation therapy or both have been evaluated. In 61% of the patients with primary brain tumors and 48% of the patients with ...
Spoudeas HA, Charmandari E, Brook CG (2003) Hypothalamo-pituitary-adrenal axis integrity after cranial irradiation for childhood posterior fossa tumours. Med Pediatr Oncol 40: 224–229 Article PubMed CAS Google Scholar Stewart D (1994) A critique of the role of the blood-brain barrier in the...
Spoudeas HA, Charmandari E, Brook CG (2003) Hypothalamo-pituitary-adrenal axis integrity after cranial irradiation for childhood posterior fossa tumours. Med Pediatr Oncol 40: 224–229 ArticlePubMedCASGoogle Scholar Stewart D(1994)A critique of the role of the blood-brain barrier in the chemothe...