Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury. In recent years, it has become clear that the function of chemokines ...
趋化因子(Chemokines)或称趋化细胞因子,是由细胞分泌的一系列小细胞因子或信号蛋白,可诱导白细胞以及包括内皮细胞和上皮细胞在内的其他类型细胞定向移动。除了在激活宿主免疫反应中发挥重要作用外,趋化因子对生物过程(包括形态形成和伤口愈合)以及癌症等疾病的发病机制也很重要。 趋化因子主要分为四个亚家族:CXC、CC、...
Miller MD, Krangel MS (1992) Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 12: 17–46 PubMed CAS Google Scholar Sozzani S, Locati M, Zhou D et al. (1995) Receptors, signal transduction and spectrum of action of monocyte ...
The CC receptors bind to the CC chemokines and are named CCR1 to 9; the CXC chemokines selectively bind to the CXC receptors, termed CXCR1 to CXCR5. This group also comprises receptors for fractalkine (CX3CR1) and lymphotactin (XCR1), as well as the Duffy antigen receptor for chemokines...
The larger part of the peptides binds to the extracellular portion of the receptors, while the flexible N-terminus of the chemokines interacts with the extracellular loops as well as the helical domains. The receptor can be modulated by small molecules, which bind to allosteric sites. Several ...
So far, approximately 50 chemokines and 18 chemokine receptors have been identified. Some chemokine receptors bind to multiple chemokines and vice versa, suggesting possible redundancies in chemokine functions. Chemokine receptors permit...
Chemokines and Chemokine Receptors Manel Juan, Servei d'Immunologia, Hospital Cl´ınic (CDB), Institut d'Investigacions Biome`diques August Pi i Sunyer, Barcelona, Catalonia, Spain Roger Colobran, Laboratori d'Immunobiologia per a la Recerca i Aplicacions Diagno` stiques (LIRAD), Banc de ...
Opioid receptor expression, signaling, and desensitization are furthermore influenced by their interactions with other GPCRs, notably chemokine receptors11,12,13. Chemokine receptors bind to chemokines, which are small (8–14 kDa) secreted chemo-attractant cytokines, regulating cellular processes like ...
nature publishing group Chemokines / Chemokine Receptors Monday, July 6 M.42. Regulation of Intestinal Dendritic Cells and Immunity by the CCX-CKR Decoy Receptor for CCL19, 21 and 25 Elinor Anderson, Iain McInnes, Robert Nibbs, Allan Mowat Glasgow University, Glasgow, United Kingdom Lymphocyte...
Recent advances in chemokines and chemokine receptors. Chemokines are a superfamily of small cytokine-like molecules which have been described primarily on the basis of their ability to mediate the migration of... A Zlotnik,J Morales,JA Hedrick - 《Critical Reviews in Immunology》 被引量: 1124发...