We explore the potential chemoprotective effect of aspirin/other anti-platelet agents on obesity-related cancers, including HCC in people with NAFLD.#We performed a retrospective cohort study of anonymised electronic medical records using the TriNetX network (Cambridge, MA, USA), a global federated ...
Monoclonal antibodies of angiogenin and plexin-B2 decrease the stemness of prostate CSCs and sensitize them to chemotherapeutic agents in vitro and in vivo.Similar content being viewed by others STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population ...
Moreover, multiple dose administrations of drugs often induce cancer MDR, which, in turn, would greatly compromise chemotherapeutic effects1,2,3,4. Therefore, it would not be very optimistic to only rely on the development of more potent chemotherapeutic agents for the treatment of MDR cancer. ...
Patients could not have received prior agents for the treatment or prevention of breast cancer. A total of 333 patients were enrolled to the study and were randomized 1:1 to receive 840 mg of intravenous atezolizumab twice weekly plus nab-paclitaxel every 2 weeks followed by atezol...
Chemosensitizers are small molecules that may improve the therapeutic index of antitumoral drugs by making tumor cells sensitive to the chemotherapeutic agents, thus overcoming treatment resistance (Caster et al., 2015). From: Nanostructures for Cancer Therapy, 2017 ...
It is important for everyone reading this blogpost to know that despite all of the hype and exclamation points and strong language about a cure or the promise of successful long-term targeted agents for metastatic breast cancer so that it can be more like a “chronic disease,” we are not...
A Study of Antisense Oligodeoxynucleotides As A Chemo-Sensitizer to Cytotoxic Agents on Proliferation of Breast Cancer Cell Lines in Vitro[J]. Cancer Research on Prevention and Treatment, 2006, 33(03): 137-140. DOI: 10.3971/j.issn.1000-8578.449 ...
Resveratrol and didox are known chemopreventive agents with potential anticancer properties. The aim of the current study is to investigate the influence of resveratrol and didox on the cytotoxicity profile of herceptin in HER-2 receptor positive and HER-2 receptor negative breast cancer cell lines ...
Chemo-resistant samples contain a threefold enrichment of inflammatory cancer-associated fibroblasts that upregulate metallothioneins. Our study reveals a deeper understanding of the intricate substructure of pancreatic ductal adenocarcinoma tumors that could help improve therapy for patients with this disease....
There has been an intensive search for chemoprotective agents for all individuals at risk for colon cancer and other gastrointestinal cancers, particularly individuals over the age of 45. One class of potentially therapeutically useful compounds are the non-steroidal antiinflammatory drugs ("NSAIDs")....