of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes ...
named bridged nucleic acid 2',4'-BNA. 10 The name “oxy-LNA” is used in this report for the parent LNA molecule, i.e., the analogue containing a 2'-oxygen atom. Synthesis of LNA Monomers LNA oligomers are prepared by oligomerisation on commercial automated DNA synthesiz- ...
The nucleic acids DNA and RNA have been studied in detail over the last 50 years and a thorough knowledge of their physico-biochemical characteristics is a key component in chemistry and biochemistry education. Many areas of nucleic acid... CJ Knill,JF Kennedy - 《International Journal of Biolog...
The present invention relates to isolated polypeptides having branching enzyme activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and...
At HitGen, our experienced chemists have curated comprehensive organic chemistry and nucleic acid chemistry knowledge, together with computational scientists and biologists to provide powerful solutions for your DNA & RNA related applications. HitGen is equipped with the specialized synthesizers to support va...
网络核酸化学 网络释义 1. 核酸化学 Wiley Online Library_百度百科 ... Neuroscience( 神经科学)Nucleic Acid Chemistry(核酸化学) Pharmacology( 药理学… baike.baidu.com|基于9个网页
Peptide Nucleic Acid (PNA) is conceptually a DNA analog, but in a chemical sense PNA bridges peptides and nucleic acids by virtue of its pseudopeptide backbone and its nucleobases. Since this mimic was introduced five years ago, convenient synthetic routes to PNA monomers as well as oligomers ...
Oligonucleotide catalysts such as ribozymes and DNAzymes can cleave RNA efficiently and specifically but are typically dependent on high concentrations of divalent cations, limiting their biological applications. A modular XNAzyme catalyst composed of 2′-deoxy-2′-fluoro-β-d-arabino nucleic acid (FAN...
摘要: Indentifing the first genetic molecule will provide the key to understanding the origin of life. RNA is an unlikely candidate but peptide nucleic acid looks promising in the role of primordial genetic material.关键词:Peptides Poly C RNA Hexoses Glucose Ribose Biogenesis Templates, Genetic ...