Uses of DNA Oligomers. Established methods of synthesis and general strategies. Types of solid supports. Protection of the nucleic bases. Thymidine. Deoxycytidine. Deoxyadenosine. Deoxyguanosine. Protection of the deoxyribose. Phosphorylation and phosphitylation. The coupling step. The final deprotection ...
The main applications of oligonucleotides in biological studies, the protecting group chemistry, the coupling procedures, and the methods for isolating and characterizing products are described. Contents. Introduction. Uses of DNA Oligomers. Established methods of synthesis and general strategies. Types of...
Recent findings have unambiguously demonstrated that DNA G-rich sequences can adopt a G-quadruplex folding in living cells, thus further validating them as... FSD Leva,P Zizza,C Cingolani,... - 《Journal of Medicinal Chemistry》 被引量: 48发表: 2013年 QSAR and Drug Design: New Developments...
A new methodology for the discovery of chalcogenides by tuning the temperature and flux ratios of systems using mixed fluxes is demonstrated, leading to the synthesis of 30 new and unreported compounds or compositions. Xiuquan Zhou , Venkata Surya Chaitanya Kolluru & Mercouri G. Kanatzidis Article...
DNA catch bonds demonstrate the art of getting stuck Biological systems have evolved bonds that strengthen under load, enabling cells to adhere in high shear flow. A DNA-based artificial motif has now been designed to mimic these catch bonds. ...
Symeres has been offering synthetic chemistry services since the inception of our legacy companies over 30 years ago, and complex custom synthesis is very much in our DNA. The majority of our synthetic chemistry services are aimed at drug discovery. However, we also carry out organic chemistry ...
semiconducting materials. Deqing Zhang (张德清), Lifeng Chi (迟力峰), and coworkers present a novel synthesis of electron-deficient bisanthene tetraimide (ATI) via a combined approach of solution synthesis and on-surface synthesis. The chemical structures, electronic states, and aromaticity of ATI...
2024年1月18日,朱听课题组在Nature Chemistry上发表论文Mirror-image trypsin digestion and sequencing of D-proteins(利用镜像胰蛋白酶实现镜像蛋白质的降解与测序)。研究者全化学合成了镜像胰蛋白酶,并利用该镜像蛋白酶降解、测序了多种镜像蛋白质,包括镜像核糖体蛋白质L25、镜像DNA聚合酶Dpo4及其Y12S突变体,并开发...
Integrated photochemical strategy for alkene synthesis from diverse substrates Despite advances, a general olefination strategy for the direct conversion of carboxylic acids, alcohols and alkanes into alkenes remains challenging owing to their inherent differences in reactivity. Now, a one-pot photochemical ...
From absolute alcohol, which refers to the common name for high-purity ethanol, to zinc and zwitterion, an amino acid formed when a hydrogen ion transfers from an acid group to an amine group, you're sure to learn more with these hundreds of important chemistry terms. ...