Specifically, markers like major histocompatibility complex class I (MHC-I) and programmed cell death ligand 1 (PD–L1) play pivotal roles in cancer immunotherapy [101, 102]. Jiang and colleagues developed an innovative system based on a bioorthogonal IEDDA reaction to monitor and correlate fluxes...
A new class of bis(azolyl) pyridine-2,6-dicarboxamides based derivatives were designed, synthesized, and characterized by employing ultrasonication methodology. The screening results reveals that, the most of the synthesized compounds possess good antibacterial, antioxidant and antifungal activities in com...
The accuracy (ACC) indicates the proportion of data correctly classified by the model among its predictions. It is useful when the class distribution of the data is uniform. If one class greatly outnumbers the other, it can be challenging to fully assess the model’s performance based solely ...
{Electrochemistry class notes}(1997-2004)by J. Baird of Brown Univ. Gases Properties of gases: matter at its simplest- a six-part "virtual textbook" treatment of the gaseous state of matter by Steve Lower. Includes numerous examples of application of kinetic molecular theory and a section on...
Synthesis and biological evaluation of triphenyl-imidazoles as a new class of antimicrobial agents Anupam Anupam, Mohammed Al-Bratty, Hassan Ahmad Alhazmi, Shamim Ahmad, Supriya Maity, Md Shamsher Alam, Waquar Ahsan 369-374 DOI:https://doi.org/10.5155/eurjchem.9.4.369-374.1785 ...
including the use of computational techniques when closely linked to experimental data the reporting of "first-in-class" new therapeutic compounds the chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanism methodological advances that are chemistry...
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Keywords: Epigenetics, Sirtuins, SIRT modulators, Drug discovery, Cancer, Neurodegeneration Background The mammalian sirtuin (SIRT) family, evolutionally conserved proteins belonging to class III histone dea- cetylases (HDACs), comprises seven members. SIRTs share a NAD+-binding catalytic domain and ...
Iron oxide nanoparticles (IONPs) are particles of iron oxide with diameters ranging from 1 to 100 nm that have application in various field, they could compose of either magnetite (Fe3O4) or maghemite (y-Fe2O3). IONPs can be synthesized using extract of different plant parts such as lea...
Oxazolidinones The oxazolidinones consists of 2- oxazolidinone as a pharmacophore and are protein synthesis inhibitors which belong to a new class of synthetic antibacterial agents. Linezolid was developed by Pharmacia and Upjohn (The company has now merged with Pfizer). PNU-100480 was also developed...