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While bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this
{Electrochemistry class notes}(1997-2004)by J. Baird of Brown Univ. Gases Properties of gases: matter at its simplest- a six-part "virtual textbook" treatment of the gaseous state of matter by Steve Lower. Includes numerous examples of application of kinetic molecular theory and a section on...
bulgaricus d-lactate dehydrogenase (ldh) gene to monitor yogurt characteristics Research articleOpen access CRISPR/Cas9-mediated gene editing of L. bulgaricus d-lactate dehydrogenase (ldh) gene to monitor yogurt characteristics G. M. M. Anwarul Hasan, Anuj Kumer Das, Mohammed A. Satter Article 100...
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these
SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones. J Neurosci. 2012;32(1):124–32. doi:10.1523/JNEUROSCI.3442-11. 2012. 8. Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY. Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide ...
Among them TMC-207 or R-207910 or Bedaquiline has been identified as the lead compound and it is currently in Phase II clinical trials.[61] TMC-207(Bedaquiline): TMC-207 is the first compound from a new class diarylquinoline. It was discovered by Johnson & Johnson through a high- ...
The mammalian sirtuin (SIRT) family, evolutionally conserved proteins belonging to class III histone deacetylases (HDACs), comprises seven members. SIRTs share a NAD+-binding catalytic domain and may act specifically on different substrates depending on the biological processes in which they are invol...
Iron oxide nanoparticles (IONPs) are particles of iron oxide with diameters ranging from 1 to 100 nm that have application in various field, they could compose of either magnetite (Fe3O4) or maghemite (y-Fe2O3). IONPs can be synthesized using extract of different plant parts such as lea...