While bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this
{Electrochemistry class notes}(1997-2004)by J. Baird of Brown Univ. Gases Properties of gases: matter at its simplest- a six-part "virtual textbook" treatment of the gaseous state of matter by Steve Lower. Includes numerous examples of application of kinetic molecular theory and a section on...
Studies towards the synthesis of (±)-reserpine: Photocyclization mediated a novel and efficient synthesis of 11,18-dimethoxy-(20α)-18,19-didehydro-yohimban-17-one Muhammad Yar, Muhammad Arshad, Muhammad Nadeem Akhtar, Sohail Anjum Shahzad, Islam Ullah Khan, Zulfiqar Ali Khan, Nisar Ullah, ...
including the use of computational techniques when closely linked to experimental data the reporting of "first-in-class" new therapeutic compounds the chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanism methodological advances that are chemistry...
SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones. J Neurosci. 2012;32(1):124–32. doi:10.1523/JNEUROSCI.3442-11. 2012. 8. Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY. Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide ...
Iron oxide nanoparticles (IONPs) are particles of iron oxide with diameters ranging from 1 to 100 nm that have application in various field, they could compose of either magnetite (Fe3O4) or maghemite (y-Fe2O3). IONPs can be synthesized using extract of different plant parts such as lea...
Among them TMC-207 or R-207910 or Bedaquiline has been identified as the lead compound and it is currently in Phase II clinical trials.[61] TMC-207(Bedaquiline): TMC-207 is the first compound from a new class diarylquinoline. It was discovered by Johnson & Johnson through a high- ...
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these
During the current study, we have synthesized thiosemicarbazide derivatives of isoniazid (3–27) through modification at terminal NH2(Fig.5) by reacting with different isothiocyanates. Thiosemicarbazide class of compounds possess the diverse biological activities, such as anti-cancer26, anti-fungal27, an...
The accuracy (ACC) indicates the proportion of data correctly classified by the model among its predictions. It is useful when the class distribution of the data is uniform. If one class greatly outnumbers the other, it can be challenging to fully assess the model’s performance based solely ...