WORDS OF CAUTION ON CHEMICALS THAT MIMIC ESTROGENPat Swift
Chemicals that mimic or antagonize thein vitroand/orin vivoactions of naturally occurring estrogens such as 17β-estradiol (E2) are typically defined as having estrogenic activity (EA) or anti-estrogenic activity, and effects on estrogen signaling represent the most common and best studied endocrine ...
Feminization of the male roach,Rutilus rutilus, a freshwater, group-spawning fish, is widespread in English rivers; among the causative agents are natural and synthetic steroidal estrogens and chemicals that mimic estrogens. In feminized male roach, concentrations of the egg-yolk protein vitellogenin ...
Chemicals are said to have EA if they mimic in vitro and/or in vivo actions of naturally occurring estrogens such as 17β-estradiol (E2). EA is the most-studied form of such endocrine disruptor activity [6, 10–12]. Chemicals with EA bind to one or more estrogen receptor (ER) subtypes...
Some of these chemicals can mimic the hormones your body produces, such as estrogen or testosterone. Other EDCs impact hormonal synthesis so that the body makes more of a hormone, less of it, or changes how it breaks down, he added. ...
The controversy surrounds not so much the matter of whether these chemicals can mimic hormones in vitro--this phenomenon has been widely accepted in the scientific world - but more whether, as a result, they can disrupt in a wildlife situation. It has, nevertheless, been acknowledged that many...
Xenobiotics that mimic or obstruct endocrine function in vertebrates and affect the function of a wide variety of physiological systems including reproduction, immunity, osmoregulation, development, and growth are termed endocrine disrupting chemicals (EDCs). EDCs are a structurally diverse group of ...
Endocrine-disrupting chemicals (EDCs) are a heterogeneous group of natural and man-made chemicals from environmental sources that mimic natural hormones. T
estrogen, E252. Despite the fact that Tmx dose was 20-fold higher than EE2dose, this EDC did not increase the peroxidase activity during 30 days of treatment. Taking into account that EE2is decomposed by a catalytic reaction triggered by peroxidases53. The possible role of peroxidases in the...
Endocrine-disrupting chemicals (EDCs) mimic the action of endogenous estrogen hormones; consequently, they can interfere with the endocrine systems of a va... K Park,IS Kwak - 《Chemosphere》 被引量: 92发表: 2010年 Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation...