2)1. For a non-binding control, maleimide-TCO-MMAE 1 was conjugated to an analogous diabody targeting the prostate specific membrane antigen (PSMA), affording nb-ADC (Fig. 2). As expected, while vc-ADC had the same uptake in LS174T and OVCAR-3 xenografts as tc-ADC, the non-binding...
2)1. For a non-binding control, maleimide-TCO-MMAE 1 was conjugated to an analogous diabody targeting the prostate specific membrane antigen (PSMA), affording nb-ADC (Fig. 2). As expected, while vc-ADC had the same uptake in LS174T and OVCAR-3 xenografts as tc-ADC, the non-binding...
characterised in that the immunochemical membrane is formed from a functionalized antigen or from the same functionalized antigen bonded to a protein, said immunochemical membrane being bonded chemically to the polysiloxane matrix by functional groups present on the same antigen or by bifunctional coupling...
16). This lack of signal could be attributed to two factors: (1) damage to the EpCAM surface protein during enzymatic digestion and/or (2) insufficient cell lysis using an antigen-retrieval buffer composed of 0.5% (w/v) SDS and 6 M urea. Regarding possibility (1): during the ...
Irradiation of tetrameric with a high-pressure mercury lamp in the presence of chloroacetamide and fractionation of the reaction product by affinity chromatography gave a derivative showing a monomeric molecular weight at pH 7.4, with an overall yield of 25%. It retained the intact ability against ...
These same lines were rapidly rejected by minor alloantigen-mismatched SWR , confirming their susceptibility to immune effector mechanisms. The failure of constitutive B7-1 expression on keratinocytes to prevent the of squamous and may reflect the limited immunogenicity of arising after initiation-pro...
A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process Exp Cell Biol, 55 (1987), pp. 295-304 CrossrefView in ScopusGoogle Scholar 9 Schaer DJ, Boretti FS, Hongegger A, et al. Molecular cloning and ch...
(lysis of red blood cells) due to red blood cell alloantibodies, which may occur intravascularly or extravascularly. Extravascular hemolysis is typically associated with antibodies of the Rh system, but several additional antibodies may also be involved (for example, antibodies reactive with antigens...
At this time active antibody synthesis to a variety of antigens can be dem- onstrated. However, there is now ample evidence that the human fetus has an immune mechanism which starts to develop as early as the 3rd or 4th month of gestational age and which is competent to respond to ...
In TNBS and oxazolone colitis models, topical administration of hapten reagents results in T-cell-mediated immunity against haptenized proteins and luminal antigens. By contrast, to generate DSS colitis models, mice orally receive DSS, causing death of epithelial cells, compromising barrier function ...